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LB244
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LB244
Catalog No. T79730
LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $198 | 35 days | |
| 5 mg | $890 | 35 days | |
| 10 mg | $1,580 | 35 days |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1]. |
| In vivo | Pharmacokinetic results in mice indicate that compound LB244, administered at 10 mg/kg orally (po) and 5 mg/kg intraperitoneally (ip), exhibits limited oral bioavailability (C max = 0.04 μM) and a short half-life (T 1/2 = 2.8 h). Its in vivo clearance rate is 2854.3 mL/min/kg [1]. |
| Molecular Weight | 537.57 |
| Formula | C30H27N5O5 |
| Cas No. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。 Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
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