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Leronlimab

🥰Excellent
Catalog No. T77059Cas No. 674782-26-4
Alias PRO 140

Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody with both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV, non-alcoholic steatohepatitis (NASH), and breast cancer.

Leronlimab

Leronlimab

🥰Excellent
Purity: 99.6% (SEC-HPLC)
Catalog No. T77059Alias PRO 140Cas No. 674782-26-4
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody with both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV, non-alcoholic steatohepatitis (NASH), and breast cancer.
Pack SizePriceAvailabilityQuantity
1 mg$198In Stock
5 mg$579In Stock
10 mg$928In Stock
25 mg$1,370In Stock
50 mg$1,850In Stock
100 mg$2,480In Stock
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Concentration:2.43 mg/mL
Purity:99.6% (SEC-HPLC)
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Product Introduction

Bioactivity
Description
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody with both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV, non-alcoholic steatohepatitis (NASH), and breast cancer.
In vitro
Leronlimab (1-140 mg/mL) binds to CCR5-positive cells up to 98% and (80-1750 μg/mL) inhibits calcium response induced by CCL5, CCL3, and CCL4 in MDA-MB-231 cells. Additionally, Leronlimab (175 and 350 mg/mL) blocks the invasion of MDA-MB-231 cells and (10 μg/mL; 72 hours) enhances the cytotoxicity of doxorubicin against these cells[1].
In vivo
Leronlimab (2 mg; intraperitoneal injection; twice a week) reduces lung metastasis in a mouse xenograft model[1].
AliasPRO 140
Chemical Properties
Molecular Weight146.66 kDa
Cas No.674782-26-4
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice.

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