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Leukotriene B5
Catalog No. T36423Cas No. 80445-66-5
Leukotriene B5 (LTB5) is a metabolite of eicosapentaenoic acid formed via the 5-lipoxygenase (5-LO) pathway, possessing diverse biological activities, including the ability to increase contraction of bullfrog lung strips ex vivo in a concentration-dependent manner.
Leukotriene B5
Catalog No. T36423Cas No. 80445-66-5
Leukotriene B5 (LTB5) is a metabolite of eicosapentaenoic acid formed via the 5-lipoxygenase (5-LO) pathway, possessing diverse biological activities, including the ability to increase contraction of bullfrog lung strips ex vivo in a concentration-dependent manner.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $353 | 35 days | |
| 50 μg | $668 | 35 days | |
| 100 μg | $1,250 | 35 days | |
| 500 μg | $4,910 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Leukotriene B5 (LTB5) is a metabolite of eicosapentaenoic acid formed via the 5-lipoxygenase (5-LO) pathway, possessing diverse biological activities, including the ability to increase contraction of bullfrog lung strips ex vivo in a concentration-dependent manner. |
| In vivo | In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells. LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platelet aggregation 8-fold less, potently than LTB4 . |
| Molecular Weight | 334.456 |
| Formula | C20H30O4 |
| Cas No. | 80445-66-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: >50 mg/mL (per Rao Maddipati) Ethanol: >50 mg/mL (per Rao Maddipati) PBS (pH 7.2): >1 mg/mL (from 13(S)-HODE) DMF: >50 mg/mL (per Rao Maddipati) |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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