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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $670 | 35 days | |
50 mg | $2,800 | 35 days |
Description | Loreclezole hydrochloride, an antiepileptic compound, functions as a selective modulator of GABA A receptors, specifically acting as a positive allosteric modulator on receptors containing β2 or β3 subunits. |
In vivo | Administering loreclezole (10, 25, 50, or 75 mg/kg, intraperitoneally, 60 minutes prior to assessing seizure threshold) to adult male Lister Hooded rats elicited a dose-dependent increase in seizure threshold, determined by the required dose of pentylenetetrazol to induce convulsion 60 minutes post-administration. Additionally, loreclezole demonstrated minimal impact on muscle tone loss, gauged by the "pull-up" test[3]. |
Alias | R 72063 hydrochloride, Loreclezole hydrochloride |
Molecular Weight | 310.99 |
Formula | C10H7Cl4N3 |
Cas No. | 2227372-56-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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