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Loreclezole
🥰Excellent
Catalog No. T5375Cas No. 117857-45-1
Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
Loreclezole
🥰Excellent
Purity: 99.94%
Catalog No. T5375Cas No. 117857-45-1
Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 41 € | In Stock | |
| 10 mg | 64 € | In Stock | |
| 25 mg | 140 € | In Stock | |
| 50 mg | 259 € | In Stock | |
| 100 mg | 386 € | In Stock | |
| 200 mg | 549 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 45 € | In Stock |
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Purity:99.94%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors. |
| In vitro | Loreclezole, at concentrations above 6 microM, enhanced the degree and rate of apparent desensitization of the whole-cell current in a concentration-dependent manner [1]. The action of loreclezole depends on the type of beta subunit present in the receptor complex; receptors containing beta 2 or beta 3 subunits have > 300-fold higher affinity for loreclezole than receptors containing a beta 1 subunit [2]. |
| Molecular Weight | 274.53 |
| Formula | C10H6Cl3N3 |
| Cas No. | 117857-45-1 |
| Smiles | Cl\C(=C/n1cncn1)c1ccc(Cl)cc1Cl |
| Relative Density. | 1.48g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (327.83 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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