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Lucerastat
😃Good
Catalog No. T32923Cas No. 141206-42-0
Alias OGT 923, NBDGJ, NB DGJ, N-(n-Butyl)deoxygalactonojirimycin, ACT 434964
Lucerastat（NBDGJ） is an orally available inhibitor of Glucosylceramide Synthase (GCS) with therapeutic potential for Fabry disease. GCS is a key enzyme in sphingolipid synthesis and inhibition of its activity reduces the accumulation of harmful substrates.
Lucerastat
😃Good
Purity: 98%
Catalog No. T32923Alias OGT 923, NBDGJ, NB DGJ, N-(n-Butyl)deoxygalactonojirimycin, ACT 434964Cas No. 141206-42-0
Lucerastat（NBDGJ） is an orally available inhibitor of Glucosylceramide Synthase (GCS) with therapeutic potential for Fabry disease. GCS is a key enzyme in sphingolipid synthesis and inhibition of its activity reduces the accumulation of harmful substrates.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $766 | 6-8 weeks | |
| 50 mg | $995 | 6-8 weeks | |
| 100 mg | $1,760 | 6-8 weeks |
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lucerastat（NBDGJ） is an orally available inhibitor of Glucosylceramide Synthase (GCS) with therapeutic potential for Fabry disease. GCS is a key enzyme in sphingolipid synthesis and inhibition of its activity reduces the accumulation of harmful substrates. |
| Alias | OGT 923, NBDGJ, NB DGJ, N-(n-Butyl)deoxygalactonojirimycin, ACT 434964 |
| Molecular Weight | 219.28 |
| Formula | C10H21NO4 |
| Cas No. | 141206-42-0 |
| Smiles | C(CCC)N1[C@H](CO)[C@H](O)[C@H](O)[C@@H](O)C1 |
| Relative Density. | 1.234 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (91.21 mM), Sonication is recommended. H2O: 20 mg/mL (91.21 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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