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Lucicebtide
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Catalog No. TP2598Cas No. 2407100-74-5
Lucicebtide (Compound ST101) acts as a selective antagonist of CCAAT/enhancer-binding protein β (C/EBPβ). By binding to the leucine zipper domain of C/EBPβ, it inhibits its dimerization and facilitates its degradation via a ubiquitin-dependent pathway. Lucicebtide halts the cell cycle at the G0/G1 phase and demonstrates cytotoxic effects on cancer cells. Additionally, it shows favorable pharmacokinetic properties and effectively suppresses tumor growth in a mouse model [1].
Lucicebtide
Lucicebtide
😃Good
Catalog No. TP2598Cas No. 2407100-74-5
Lucicebtide (Compound ST101) acts as a selective antagonist of CCAAT/enhancer-binding protein β (C/EBPβ). By binding to the leucine zipper domain of C/EBPβ, it inhibits its dimerization and facilitates its degradation via a ubiquitin-dependent pathway. Lucicebtide halts the cell cycle at the G0/G1 phase and demonstrates cytotoxic effects on cancer cells. Additionally, it shows favorable pharmacokinetic properties and effectively suppresses tumor growth in a mouse model [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry |
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Chemical Properties
| Description | Lucicebtide (Compound ST101) acts as a selective antagonist of CCAAT/enhancer-binding protein β (C/EBPβ). By binding to the leucine zipper domain of C/EBPβ, it inhibits its dimerization and facilitates its degradation via a ubiquitin-dependent pathway. Lucicebtide halts the cell cycle at the G0/G1 phase and demonstrates cytotoxic effects on cancer cells. Additionally, it shows favorable pharmacokinetic properties and effectively suppresses tumor growth in a mouse model [1]. |
| Molecular Weight | 4724.46 |
| Formula | C208H345N69O55S |
| Cas No. | 2407100-74-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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