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LY2606368 HCl (1234015-52-1 free base)
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Catalog No. T22957
Alias LY2606368 HCl
LY2606368 HCl is a selective ATP competitive inhibitor of checkpoint kinase 1 (IC50: 1.5nM in SW1990 cells).
LY2606368 HCl (1234015-52-1 free base)
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Catalog No. T22957Alias LY2606368 HCl
LY2606368 HCl is a selective ATP competitive inhibitor of checkpoint kinase 1 (IC50: 1.5nM in SW1990 cells).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $207 | Backorder | |
| 25 mg | $618 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | LY2606368 HCl is a selective ATP competitive inhibitor of checkpoint kinase 1 (IC50: 1.5nM in SW1990 cells). |
| In vitro | LY2606368 HCl is an ATP-competitive inhibitor of CHK1 and is undergoing clinical trials currently. It inhibits the auto-phosphorylation of CHK1 and induces the phosphorylation of H2AX in cancer cells. In the pancreatic cell line SW1990, LY2606368 HCl significantly inhibits cell proliferation (IC50: 1.5nM). LY2606368 HCl also exerts potent anti-tumor activity in the SW1990 xenograft model. Besides that, in the orthotopic SKVO3 model, the treatment of LY2606368 HCl is found to inhibit tumor growth and reduce the incidence of metastases and accumulation. However, LY2606368 HCl is only administered intravenously due to its poor oral bioavailability [1][2][3]. |
| Alias | LY2606368 HCl |
| Molecular Weight | 401.85 |
| Formula | C18H20ClN7O2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: > 6.63 mg/mL, Heating is recommended. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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