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Prexasertib mesylate

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Catalog No. T4310L2Cas No. 1234015-55-4
Alias LY-2606368, LY2606368, LY 2606368

Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe and antitumor effects through CHK1-dependent mechanisms. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.

Prexasertib mesylate
Other Forms of Prexasertib mesylate:

Prexasertib mesylate

😃Good
Catalog No. T4310L2Alias LY-2606368, LY2606368, LY 2606368Cas No. 1234015-55-4
Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe and antitumor effects through CHK1-dependent mechanisms. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.
Pack SizePriceAvailabilityQuantity
25 mg1.444 €1-2 weeks
50 mg1.881 €1-2 weeks
100 mg2.375 €1-2 weeks
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Product Introduction

Bioactivity
Description
Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe and antitumor effects through CHK1-d
Targets&IC50
Chk2:8 nM (IC50), Chk1:<1 nM (IC50), Chk1:0.9 nM (Ki)
AliasLY-2606368, LY2606368, LY 2606368
Chemical Properties
Molecular Weight461.49
FormulaC19H23N7O5S
Cas No.1234015-55-4
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

Prexasertib mesylatePrexasertib Mesylate
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