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Description | m-PEG10-CH2COOH, a PEG-based linker for PROTACs, connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells. |
In vitro | PROTACs, comprising two ligands joined by a linker—one binding to an E3 ubiquitin ligase and the other to the target protein—harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Molecular Weight | 530.6 |
Formula | C23H46O13 |
Cas No. | 908258-58-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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