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Mal-PEG2-NHS, a PEG-based linker for PROTACs, joins two essential ligands critical for forming PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.
Description | Mal-PEG2-NHS, a PEG-based linker for PROTACs, joins two essential ligands critical for forming PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells. |
In vitro | PROTACs, comprising two distinct ligands connected by a linker—one for an E3 ubiquitin ligase and one for the target protein—exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Alias | Mal-PEG2-NHS |
Molecular Weight | 340.288 |
Formula | C14H16N2O8 |
Cas No. | 329364-72-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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