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Description | Methylamino-PEG4-Boc is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands critical for producing PROTAC molecules, thereby enabling selective protein degradation via the ubiquitin-proteasome system within cells. |
In vitro | PROTACs utilize two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other targeting the desired protein. Through the intracellular ubiquitin-proteasome system, PROTACs selectively degrade these target proteins[1]. |
Alias | Methylamino-PEG4-t-butyl ester |
Molecular Weight | 335.44 |
Formula | C16H33NO6 |
Cas No. | 1621616-14-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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