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Methylene Violet 3RAX is a cationic dye, a potential photosensitizer in photodynamic therapy, with antitumor activity that alters the molecular structure of DNA, disrupts the modules of DNA, and induces the production of reactive monoclinic oxygen species, which are used to stain the mitochondria of cells.Methylene Violet 3RAX inhibits the subcellular localization of cancer cells by severing the Methylene Violet 3RAX inhibits subcellular localization of cancer cells, leading to cell death by cutting DNA strands in tumor cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $32 | In Stock | |
25 mg | $50 | In Stock | |
50 mg | $72 | In Stock | |
100 mg | $98 | In Stock | |
500 mg | $256 | In Stock |
Description | Methylene Violet 3RAX is a cationic dye, a potential photosensitizer in photodynamic therapy, with antitumor activity that alters the molecular structure of DNA, disrupts the modules of DNA, and induces the production of reactive monoclinic oxygen species, which are used to stain the mitochondria of cells.Methylene Violet 3RAX inhibits the subcellular localization of cancer cells by severing the Methylene Violet 3RAX inhibits subcellular localization of cancer cells, leading to cell death by cutting DNA strands in tumor cells. |
Targets&IC50 | BChE (human plasma):0.51 μM (Ki), AChE (human erythrocyte):1.58 μM (Ki) |
In vitro | Methylene Violet 3RAX was able to inhibit human erythrocyte AChE and human plasma BChE with Ki of 1.58 μM and 0.51 μM, respectively. [2] It also exhibited antitumor activity, which is achieved by cleaving DNA strands in tumor cells. Methylene Violet 3RAX significantly enhances DNA cleavage in the concentration range of 0-400 µM. At a concentration of 300 µM, its DNA photocleavage activity exceeded 60%. [1] |
Molecular Weight | 378.9 |
Formula | C22H23ClN4 |
Cas No. | 4569-86-2 |
Smiles | [Cl-].N=1C=2C=CC(N)=CC2[N+](C=3C=CC=CC3)=C4C=C(C=CC14)N(CC)CC |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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