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Mirin

🥰Excellent
Catalog No. T60273Cas No. 299953-00-7
Alias 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one

Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor that inhibits MRN-dependent ATM activation without affecting ATM protein kinase activity. It also inhibits Mre11-associated exonuclease activity, thereby disrupting DNA double-strand break repair.Mirin induces cell cycle arrest in G1 phase.

Mirin

Mirin

🥰Excellent
Purity: 99.24%
Catalog No. T60273Alias 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-oneCas No. 299953-00-7
Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor that inhibits MRN-dependent ATM activation without affecting ATM protein kinase activity. It also inhibits Mre11-associated exonuclease activity, thereby disrupting DNA double-strand break repair.Mirin induces cell cycle arrest in G1 phase.
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1 mg$30 In Stock
5 mg$50 In Stock
10 mg$80 In Stock
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Purity:99.24%
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Product Introduction

Bioactivity
Description
Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor that inhibits MRN-dependent ATM activation without affecting ATM protein kinase activity. It also inhibits Mre11-associated exonuclease activity, thereby disrupting DNA double-strand break repair.Mirin induces cell cycle arrest in G1 phase.
In vitro
Mirin inhibits H2AX phosphorylation with an IC5​​0 value of 66 μM.
Mirin inhibits ATM-dependent phosphorylation of downstream targets Nbs1 and Chk2 as well as MRN-dependent ATM autophosphorylation at Ser1981 in response to DSBs.
Mirin treatment (50, 100 μM) of TOSA4 cells induced a significant G2 arrest.
Mirin (10-100 μM) inhibits homology-dependent DNA repair in TOSA4 cells. [1]
Alias5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one
Chemical Properties
Molecular Weight220.25
FormulaC10H8N2O2S
Cas No.299953-00-7
SmilesO=C1N=C(SC1=CC2=CC=C(O)C=C2)N
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | store at 4°C | Shipping with blue ice.
Solubility Information
DMF: 60 mg/mL (272.42 mM), Sonication is recommended.
Solution Preparation Table
DMF
1mg5mg10mg50mg
1 mM4.5403 mL22.7015 mL45.4030 mL227.0148 mL
5 mM0.9081 mL4.5403 mL9.0806 mL45.4030 mL
10 mM0.4540 mL2.2701 mL4.5403 mL22.7015 mL
20 mM0.2270 mL1.1351 mL2.2701 mL11.3507 mL
50 mM0.0908 mL0.4540 mL0.9081 mL4.5403 mL
100 mM0.0454 mL0.2270 mL0.4540 mL2.2701 mL

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