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Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor that inhibits MRN-dependent ATM activation without affecting ATM protein kinase activity. It also inhibits Mre11-associated exonuclease activity, thereby disrupting DNA double-strand break repair.Mirin induces cell cycle arrest in G1 phase.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $50 | In Stock | |
10 mg | $80 | In Stock |
Description | Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor that inhibits MRN-dependent ATM activation without affecting ATM protein kinase activity. It also inhibits Mre11-associated exonuclease activity, thereby disrupting DNA double-strand break repair.Mirin induces cell cycle arrest in G1 phase. |
In vitro | Mirin inhibits H2AX phosphorylation with an IC50 value of 66 μM. Mirin inhibits ATM-dependent phosphorylation of downstream targets Nbs1 and Chk2 as well as MRN-dependent ATM autophosphorylation at Ser1981 in response to DSBs. Mirin treatment (50, 100 μM) of TOSA4 cells induced a significant G2 arrest. Mirin (10-100 μM) inhibits homology-dependent DNA repair in TOSA4 cells. [1] |
Alias | 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one |
Molecular Weight | 220.25 |
Formula | C10H8N2O2S |
Cas No. | 299953-00-7 |
Smiles | O=C1N=C(SC1=CC2=CC=C(O)C=C2)N |
Storage | keep away from direct sunlight,keep away from moisture | store at 4°C | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMF: 60 mg/mL (272.42 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMF
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