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MK-6884

Name: MK-6884
Brand: TargetMol
SKU: T39545
Price: 51 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T39545Cas No. 2102194-04-5

MK-6884, a positive allosteric modulator (PAM) of M4 muscarinic receptors, exhibits a high affinity (Ki = 0.19 nM). It is a valuable compound for the investigation of neurodegenerative diseases. Additionally, MK-6884 can be efficiently radiolabeled with carbon-11, enabling its use as a PET imaging agent.

MK-6884

🥰Excellent

Catalog No. T39545Cas No. 2102194-04-5

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Product Introduction

Bioactivity

Description	MK-6884, a positive allosteric modulator (PAM) of M4 muscarinic receptors, exhibits a high affinity (Ki = 0.19 nM). It is a valuable compound for the investigation of neurodegenerative diseases. Additionally, MK-6884 can be efficiently radiolabeled with carbon-11, enabling its use as a PET imaging agent.
In vitro	MK-6884 (compound 13; 0-22 μM) functions as a positive allosteric modulator (PAM) of acetylcholine (ACh) in a cell-based calcium (Ca 2+) mobilization assay, with an effective concentration (EC 50) of 27 nM[1].
In vivo	[11 C]MK-6884 (compound 13), with a non-displaceable binding potential (BP_ND) of 0.83, effectively penetrates the blood-brain barrier and targets M4 receptors in the rhesus monkeys' brain, as indicated by its distribution following a single intravenous dose of approximately 185 MBq, under 2 μg[1].

Chemical Properties

Molecular Weight	411.509
Formula	C₂₅H₂₅N₅O
Cas No.	2102194-04-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MK6884MK-6884MK 6884