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MK-6884

Name: MK-6884
Brand: TargetMol
SKU: T39545
Price: 172 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T39545Cas No. 2102194-04-5

MK-6884, a positive allosteric modulator (PAM) of M4 muscarinic receptors, exhibits a high affinity (Ki = 0.19 nM). It is a valuable compound for the investigation of neurodegenerative diseases. Additionally, MK-6884 can be efficiently radiolabeled with carbon-11, enabling its use as a PET imaging agent.

MK-6884

Catalog No. T39545Cas No. 2102194-04-5

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Product Introduction

Bioactivity

Description	MK-6884, a positive allosteric modulator (PAM) of M4 muscarinic receptors, exhibits a high affinity (Ki = 0.19 nM). It is a valuable compound for the investigation of neurodegenerative diseases. Additionally, MK-6884 can be efficiently radiolabeled with carbon-11, enabling its use as a PET imaging agent.
In vitro	MK-6884 (compound 13; 0-22 μM) functions as a positive allosteric modulator (PAM) of acetylcholine (ACh) in a cell-based calcium (Ca 2+) mobilization assay, with an effective concentration (EC 50) of 27 nM[1].
In vivo	[11 C]MK-6884 (compound 13), with a non-displaceable binding potential (BP_ND) of 0.83, effectively penetrates the blood-brain barrier and targets M4 receptors in the rhesus monkeys' brain, as indicated by its distribution following a single intravenous dose of approximately 185 MBq, under 2 μg[1].

Chemical Properties

Molecular Weight	411.509
Formula	C₂₅H₂₅N₅O
Cas No.	2102194-04-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

MK6884MK-6884MK 6884