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N,N-Dimethylsphingosine
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Catalog No. T23045Cas No. 119567-63-4
Alias N,N-Dimethylsphingosine (d18:1), DMS, D-erythro-N,N-dimethylsphingosin
N,N-Dimethylsphingosine, an endogenous metabolite, is a potent competitive sphingosine kinase (SphK) inhibitor that selectively inhibits sphingosine phosphorylation without affecting its N-acylation.DMS is elevated in models of neuropathic pain, and may mediate mechanical nociception by increasing the release of IL-1β and MCP-1.
N,N-Dimethylsphingosine
😃Good
Catalog No. T23045Alias N,N-Dimethylsphingosine (d18:1), DMS, D-erythro-N,N-dimethylsphingosinCas No. 119567-63-4
N,N-Dimethylsphingosine, an endogenous metabolite, is a potent competitive sphingosine kinase (SphK) inhibitor that selectively inhibits sphingosine phosphorylation without affecting its N-acylation.DMS is elevated in models of neuropathic pain, and may mediate mechanical nociception by increasing the release of IL-1β and MCP-1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 35 days | |
| 10 mg | Inquiry | 35 days | |
| 25 mg | Inquiry | 35 days | |
| 50 mg | Inquiry | 35 days |
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CitedSelect Batch
Concentration:25.0 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | N,N-Dimethylsphingosine, an endogenous metabolite, is a potent competitive sphingosine kinase (SphK) inhibitor that selectively inhibits sphingosine phosphorylation without affecting its N-acylation.DMS is elevated in models of neuropathic pain, and may mediate mechanical nociception by increasing the release of IL-1β and MCP-1. |
| In vitro | Methods: RAW264.7 cells were treated with N,N-Dimethylsphingosine (0-5μM, 24 hours), and cell viability was determined by MTT assay. Results: N,N-Dimethylsphingosine can inhibit the growth of RAW264.7 cells with an IC50 value of 2.3μM. [1] |
| Alias | N,N-Dimethylsphingosine (d18:1), DMS, D-erythro-N,N-dimethylsphingosin |
| Molecular Weight | 327.55 |
| Formula | C20H41NO2 |
| Cas No. | 119567-63-4 |
| Smiles | CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)N(C)C |
| Relative Density. | 0.921 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 20 mg/mL (61.06 mM), Sonication is recommended. DMSO: 5 mg/mL (15.26 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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