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ASP-4058

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Purity:99.51%

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COA HNMR HPLC LCMS

ASP-4058

Catalog No. T10385Cas No. 952565-91-2

ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice.

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Pack Size	Price	Availability
1 mg	$119	In Stock
5 mg	$297	In Stock
10 mg	$488	In Stock
25 mg	$798	In Stock
50 mg	$1,090	In Stock
100 mg	$1,480	In Stock
500 mg	$2,930	In Stock

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Product Introduction

Bioactivity

Description	ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice.
In vitro	ASP4058 (100 nM) significantly reduced FITC-dextran leakage through an endothelial monolayer and suppressed the migration of macrophages across the monolayer in vitro by using a Transwell system.[2]
In vivo	ASP4058 (0.1 and 0.3 mg/kg; p.o.; daily for day 12 to day 45) maintains the clinical score at a relatively low level and the cumulative clinical scores (18-45 dpi) among the groups treated with 0.1 and 0.3 mg/kg dosages are 6.90±2.85 and 5.60±2.21, respectively in mice. The ED50 value for ASP4058 is 0.063 mg/kg.[1] ASP4058 (0.03, 0.1, and 0.3 mg/kg; p.o., daily for 21 days) reduces the clinical score in a dose-dependent manner and the cumulative clinical score from day 0 to 21 dpi at 0.03, 0.1, and 0.3 mg/kg are 15.5±1.48, 9.50±2.17 and 1.17±1.17, respectively, while that of the vehicle-treated group is 15.5±0.619 in rats.[1]

Chemical Properties

Molecular Weight	442.31
Formula	C19H12F6N4O2
Cas No.	952565-91-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 70 mg/mL (158.26 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2609 mL	11.3043 mL	22.6086 mL	113.0429 mL
5 mM	0.4522 mL	2.2609 mL	4.5217 mL	22.6086 mL
10 mM	0.2261 mL	1.1304 mL	2.2609 mL	11.3043 mL
20 mM	0.1130 mL	0.5652 mL	1.1304 mL	5.6521 mL
50 mM	0.0452 mL	0.2261 mL	0.4522 mL	2.2609 mL
100 mM	0.0226 mL	0.1130 mL	0.2261 mL	1.1304 mL

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