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N,N'-Dinitrosopiperazine

Name: N,N'-Dinitrosopiperazine
Brand: TargetMol
SKU: T81720
Rating: 4.5 (1 reviews)

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Catalog No. T81720Cas No. 140-79-4

Alias DNPZ, 1,4-Dinitrosopiperazine

N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen that targets the nasopharyngeal epithelium to promote nasopharyngeal carcinoma (NPC) metastasis by modulating various signaling pathways through protein phosphorylation, notably phosphorylating LYRIC at serine 568 [1].

N,N'-Dinitrosopiperazine

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Catalog No. T81720Alias DNPZ, 1,4-DinitrosopiperazineCas No. 140-79-4

Pack Size	Price	Availability	Quantity
5 mg	Inquiry	8-10 weeks
50 mg	Inquiry	8-10 weeks

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Product Introduction

Bioactivity

Description	N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen that targets the nasopharyngeal epithelium to promote nasopharyngeal carcinoma (NPC) metastasis by modulating various signaling pathways through protein phosphorylation, notably phosphorylating LYRIC at serine 568 [1].
In vitro	N,N'-Dinitrosopiperazine (referred to herein as 0.) exhibits specific activity within chemical processes by engaging in reactions characteristic to its molecular structure.
In vivo	N,N'-Dinitrosopiperazine (administered via tail vein injection; 40 mg/kg; 30 days) suppresses cell motility and invasion while promoting nasopharyngeal carcinoma (NPC) metastasis in vivo. Immunohistochemistry (IHC) reveals that phospho-LYRIC levels are elevated in the metastatic tumors of DNP-treated mice compared to untreated controls [1].
Alias	DNPZ, 1,4-Dinitrosopiperazine

Chemical Properties

Molecular Weight	144.13
Formula	C₄H₈N₄O₂
Cas No.	140-79-4

Storage & Solubility Information

Storage

Shipping with blue ice.

Solubility Information

DMSO: 3 mg/mL (20.81 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.9382 mL	34.6909 mL	69.3818 mL	346.9090 mL
5 mM	1.3876 mL	6.9382 mL	13.8764 mL	69.3818 mL
10 mM	0.6938 mL	3.4691 mL	6.9382 mL	34.6909 mL
20 mM	0.3469 mL	1.7345 mL	3.4691 mL	17.3455 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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