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NB-598 Maleate

Catalog No. T12199Cas No. 155294-62-5

NB-598 Maleate is a competitive squalene epoxidase (SE) inhibitor.

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Pack Size	Price	Availability
25 mg	$626	1-2 weeks
50 mg	$814	1-2 weeks
100 mg	$1,320	1-2 weeks

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Product Introduction

Bioactivity

Description

NB-598 Maleate is a competitive squalene epoxidase (SE) inhibitor.

In vitro

NB-598, an inhibitor of squalene epoxidase, on cholesterol absorption from the intestinal epithelia.?NB-598 (10 microM) inhibited the synthesis of sterol and sterol ester from [14C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG).?When labeled lipid was apically loaded as a micellar lipid solution into Caco-2 cell cultures, NB-598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG[1].

Chemical Properties

Molecular Weight	565.74
Formula	C31H35NO5S2
Cas No.	155294-62-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (176.76 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7676 mL	8.8380 mL	17.6760 mL	88.3798 mL
5 mM	0.3535 mL	1.7676 mL	3.5352 mL	17.6760 mL
10 mM	0.1768 mL	0.8838 mL	1.7676 mL	8.8380 mL
20 mM	0.0884 mL	0.4419 mL	0.8838 mL	4.4190 mL
50 mM	0.0354 mL	0.1768 mL	0.3535 mL	1.7676 mL
100 mM	0.0177 mL	0.0884 mL	0.1768 mL	0.8838 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc