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NCT-501 hydrochloride

Name: NCT-501 hydrochloride
Brand: TargetMol
SKU: T39485
Rating: 4.5 (1 reviews)

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Catalog No. T39485Cas No. 2080306-22-3

NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM).

NCT-501 hydrochloride

😃Good

Catalog No. T39485Cas No. 2080306-22-3

Pack Size	Price	Availability
1 mg	$143	35 days
5 mg	$583	35 days
10 mg	$960	35 days
25 mg	$2,210	35 days

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Product Introduction

Bioactivity

Description	NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM).
Targets&IC50	ALDH1A1 (human):40 nM (IC50)
In vitro	NCT-501 exhibited a 16% reduction in activity against the Cal-27 CisR cell line at a concentration of 20 nM; however, this difference was not statistically significant[1].
In vivo	NCT-501, administered intratracheally at a dose of 100 μg/animal on an alternate-day schedule for 20 days, demonstrates a 78% reduction in tumor growth in Cal-27 CisR-derived xenografts[1].

Chemical Properties

Molecular Weight	452.98
Formula	C₂₁H₃₃ClN₆O₃
Cas No.	2080306-22-3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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