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NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $143 | 35 days | |
5 mg | $583 | 35 days | |
10 mg | $960 | 35 days | |
25 mg | $2,210 | 35 days |
Description | NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM). |
Targets&IC50 | ALDH1A1 (human):40 nM (IC50) |
In vitro | NCT-501 exhibited a 16% reduction in activity against the Cal-27 CisR cell line at a concentration of 20 nM; however, this difference was not statistically significant[1]. |
In vivo | NCT-501, administered intratracheally at a dose of 100 μg/animal on an alternate-day schedule for 20 days, demonstrates a 78% reduction in tumor growth in Cal-27 CisR-derived xenografts[1]. |
Molecular Weight | 452.98 |
Formula | C21H33ClN6O3 |
Cas No. | 2080306-22-3 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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