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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $170 | 35 days | |
10 mg | $325 | 35 days | |
25 mg | $755 | 35 days |
Description | Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells. |
Molecular Weight | 419.34 |
Formula | C19H18F5NO4 |
Cas No. | 54280-71-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: 20 mg/mL Ethanol: 15 mg/mL Methanol: 100 mg/mL |
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