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NH-bis(m-PEG8)

Catalog No. T16298Cas No. 2055013-64-2

NH-bis(m-PEG8) is a PEG-based linker for PROTACs joining two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

NH-bis(m-PEG8)

NH-bis(m-PEG8)

Catalog No. T16298Cas No. 2055013-64-2
NH-bis(m-PEG8) is a PEG-based linker for PROTACs joining two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.
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Product Introduction

Bioactivity
Description
NH-bis(m-PEG8) is a PEG-based linker for PROTACs joining two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.
In vitro
PROTACs, consisting of two distinct ligands linked together— one for an E3 ubiquitin ligase and the other for the target protein— utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Chemical Properties
Molecular Weight749.92
FormulaC34H71NO16
Cas No.2055013-64-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

NH-bis(m-PEG-8)NH-bis(m-PEG8)NH bis(m PEG8)NHbis(mPEG8)
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