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NSC-70220
😃Good
Catalog No. T12978Cas No. 4551-00-2
Alias SOS1-IN-1
SOS1-IN-1 is an inhibitor of SOS1.
NSC-70220
😃Good
Catalog No. T12978Alias SOS1-IN-1Cas No. 4551-00-2
SOS1-IN-1 is an inhibitor of SOS1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $242 | 5 days | |
| 5 mg | $297 | 5 days | |
| 25 mg | $987 | 6-8 weeks | |
| 50 mg | $1,360 | 6-8 weeks | |
| 100 mg | $1,860 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SOS1-IN-1 is an inhibitor of SOS1. |
| In vitro | SOS1-IN-1 (40 μM) and NSC-658497(30 μM) result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of SOS1-IN-1 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-ERK. |
| Alias | SOS1-IN-1 |
| Molecular Weight | 325.36 |
| Formula | C22H15NO2 |
| Cas No. | 4551-00-2 |
| Relative Density. | 1.321 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12.5 mg/mL (38.42 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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