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Nylidrin

Name: Nylidrin
Brand: TargetMol
SKU: T69239
Rating: 4.5 (1 reviews)

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Catalog No. T69239Cas No. 447-41-6

Alias Buphenine

Nylidrin (Buphenine) is a non-piperidine-related compound with antihypertensive activity, exhibiting antiviral activity by targeting hemagglutinin 2 of the influenza virus, mediating membrane fusion.

Nylidrin

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Catalog No. T69239Alias BuphenineCas No. 447-41-6

Nylidrin (Buphenine) is a non-piperidine-related compound with antihypertensive activity, exhibiting antiviral activity by targeting hemagglutinin 2 of the influenza virus, mediating membrane fusion.

Pack Size	Price	Availability
5 mg	$78	35 days
10 mg	$143	35 days
25 mg	$290	35 days
50 mg	$498	35 days

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Nylidrin (Buphenine) is a non-piperidine-related compound with antihypertensive activity, exhibiting antiviral activity by targeting hemagglutinin 2 of the influenza virus, mediating membrane fusion.
In vitro	Nylidrin is a potent antagonist of NR1A/2B receptor expressed in Xenopus oocytes with IC50 = 0.18 μM. Nylidrin inhibits the NMDA response in cultured rat cortical neurons with a potency and mechanism of action similar to that of NR1A/2B receptors. [1] Nylidrin (0, 40, and 400 μM) targets hemagglutinin 2 (HA2) -mediated membrane fusion by blocking the conformational change of HA at acidic pH. [2]
In vivo	In mouse models, preincubation of mouse influenza A virus (H1N1) with Nylidrin completely blocked intranasal viral infection. [2]
Alias	Buphenine

Chemical Properties

Molecular Weight	299.41
Formula	C₁₉H₂₅NO₂
Cas No.	447-41-6
Smiles	OC1=CC=C(C=C1)C(O)C(NC(C)CCC=2C=CC=CC2)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Nylidrin