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OB-1
🥰Excellent
Catalog No. T28223Cas No. 300803-69-4
Alias OB1
OB-1 is a protein-like protein-3 (STOML3) inhibitor, inhibiting adipogenesis and lipid droplet growth by downregulating the PPARγ pathway. OB-1 inhibits adipogenesis and lipid droplet growth by interfering with the self-association of stomatin.
OB-1
🥰Excellent
Catalog No. T28223Alias OB1Cas No. 300803-69-4
OB-1 is a protein-like protein-3 (STOML3) inhibitor, inhibiting adipogenesis and lipid droplet growth by downregulating the PPARγ pathway. OB-1 inhibits adipogenesis and lipid droplet growth by interfering with the self-association of stomatin.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $68 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $163 | In Stock | |
| 50 mg | $248 | In Stock | |
| 100 mg | $367 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | OB-1 is a protein-like protein-3 (STOML3) inhibitor, inhibiting adipogenesis and lipid droplet growth by downregulating the PPARγ pathway. OB-1 inhibits adipogenesis and lipid droplet growth by interfering with the self-association of stomatin. |
| In vitro | OB-1 (3 h) treatment reduced the mechanical conduction current of N2a cells with an IC50 of 10 nM. [1] |
| In vivo | OB-1 (250-500 pmol/ capsule, injected subcutaneously) reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silenced mechanoreceptors in mice. OB-1 (250 pmol/ capsule, subcutaneous injection) alleviates painful diabetic neuropathy in mice. [1] |
| Alias | OB1 |
| Molecular Weight | 407.38 |
| Formula | C21H17N3O6 |
| Cas No. | 300803-69-4 |
| Smiles | O=C(OCC)C1=C(OC=2C=CC(OC3=C(N=CN3C)N(=O)=O)=CC21)C=4C=CC=CC4 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (19.64 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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