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Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 245 € | In Stock | |
5 mg | 609 € | In Stock | |
10 mg | 867 € | In Stock | |
25 mg | 1.301 € | In Stock | |
50 mg | 1.757 € | In Stock | |
100 mg | 2.375 € | In Stock |
Description | Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia. |
In vivo | CG 3509 (2 μg; intrathecal administration; twice daily for 5 days; adult rats) on wet-dog shake (WDS) and forepaw-licking (FPL) behaviours and spinal cord TRH and indoleamine levels and choline acetyltransferase (ChAT) activity was examined. A rapid behavioural tolerance developed to repeated intrathecal injections of CG 3509; WDS and FPL behaviours were reduced by 57% and 34%, respectively, following the fifth injection and remained reduced at the ninth injection. Repeated CG 3509 administration selectively elevated ChAT activity and the level of 5-hydroxytryptamine (5-HT) in the ventral but not in the dorsal horn of the spinal cord, while 5-hydroxy indole acetic acid and TRH levels were unaltered in either region.[2] |
Alias | Orotireline, CG 3509 |
Molecular Weight | 389.37 |
Formula | C16H19N7O5 |
Cas No. | 62305-86-6 |
Smiles | C([C@H](CC1=CN=CN1)NC(=O)C2=CC(=O)NC(=O)N2)(=O)N3[C@H](C(N)=O)CCC3 |
Relative Density. | 1.31g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (128.41 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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