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PACAP-38 (31-38), human, mouse, rat acetate
🥰Excellent
Catalog No. TP1618L
Alias PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base)
PACAP-38 (31-38), human, mouse, rat acetate is an activator of PAC1 receptor. PACAP-38 (31-38), human, mouse, rat acetate demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production and can
PACAP-38 (31-38), human, mouse, rat acetate
🥰Excellent
Purity: 99.92%
Catalog No. TP1618LAlias PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base)
PACAP-38 (31-38), human, mouse, rat acetate is an activator of PAC1 receptor. PACAP-38 (31-38), human, mouse, rat acetate demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production and can
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $137 | In Stock | |
| 5 mg | $412 | In Stock | |
| 10 mg | $597 | In Stock | |
| 25 mg | $953 | In Stock | |
| 50 mg | $1,290 | In Stock | |
| 100 mg | $1,730 | In Stock | |
| 500 mg | $3,490 | In Stock |
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View MoreInhibitors Related to "PACAP-38 (31-38), human, mouse, rat acetate"
PA-8
T41005878437-15-1
PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo.
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PACAP (1-27), human, ovine, rat acetate
PACAP 1-27 acetate, PACAP (1-27), human, ovine, rat acetate(127317-03-7 free base)
TP1070L
PACAP (1-27), human, ovine, rat acetate (PACAP 1-27 acetate) is a novel neuropeptides originally isolated from bovine hypothalamus, also found in humans and rats.
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PACAP 1-38 acetate
TP1878L
PACAP 1-38 acetate is a pituitary adenylate cyclase activating polypeptide (PACAP) analogue. PACAP 1-38 acetate binds to PACAP type I receptor(IC50 = 4 nM) and PACAP type II VIP2 receptor(IC50 = 1 nM) but not to PACAP type II, VIP1 receptor.
- $163
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PACAP (1-38), human, ovine, rat
Pituitary Adenylate Cyclase Activating Polypeptide 38, PACAP 1-38
TP1878137061-48-4
PACAP (1-38), human, ovine, rat (Pituitary Adenylate Cyclase Activating Polypeptide 38), is a neuropeptide comprising 38 amino acid residues.
- $143
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PAC1R antagonist 1
T781052305204-24-2
PAC1R antagonist 1 is an orally active PAC1 receptor antagonist that inhibits abnormal pain induced by pituitary adenylate cyclase-activating polypeptide (PACAP) and nerve damage, and may be used in the study of neoplasms and immune-related disorders.
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PACAP (6-38), human, ovine, rat acetate
TP1722L
PACAP (6-38), human, ovine, rat acetate is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively.
- $89
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PACAP-related Peptide (rat) (trifluoroacetate salt)
T37435
PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervical, uterine horn, fallopian tube, and ovarian tissues from the rat female genital tract and is present in extracts of male testis tissue.
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PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)
T36427
Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, SK-N-MC, and T47D cells). In vivo, in newborn pigs, PACAP (6-27) (10 μM) inhibits vasodilation of pial arterioles induced by PACAP (1-27) and PACAP (1-38) . It also inhibits PACAP (1-27)-stimulated increases in plasma insulin and glucagon levels and pancreatic venous blood flow in dogs when administered locally to the pancreas at a dose of 500 μg.
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PACAP-related Peptide (human) (trifluoroacetate salt)
T36428
PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in normal human pancreas and adrenal gland tissue and in some tumors that produce vasoactive intestinal peptide (VIP). PRP (1-29) is secreted by CHO-K1 cells that express human recombinant preproPACAP.
- $891
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Purity:99.92%
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Product Introduction
Bioactivity
Chemical Properties
| Description | PACAP-38 (31-38), human, mouse, rat acetate is an activator of PAC1 receptor. PACAP-38 (31-38), human, mouse, rat acetate demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production and can |
| In vitro | PACAP-38 (31-38), human, mouse, rat acetate (0.01-10 nM; HEK 293 cells) stimulates neural cells to express endogenous PAC1 receptors by cAMP accumulation and by an increase in cytosolic free calcium and induces elevation of the intracellular Ca2+ concentration in a dose-dependent manner with an EC50 value of 0.81 nM. PACAP-38 (31-38), human, mouse, rat acetate (300 nM; 4 h) stimulates the generation of APPsα in neural cells[1]. PACAP-38 (31-38), human, mouse, rat acetate (0.01 nM; 48 h) elicits potent and efficacious stimulation of NPY secretion from SCG neuronal cultures[2]. PACAP-38 (31-38), human, mouse, rat acetate (100 nM; 14 d) produces sustained stimulated NPY and catecholamine secretionmpathetic neurons[2]. PACAP-38 (31-38), human, mouse, rat acetate (100 nM; 2 min; NCI-H838 cells) induces EGFR, HER2, and ERK tyrosine phosphorylation. PACAP-38 (31-38), human, mouse, rat acetate (10 nM; 48 h) stimulates the growth of NCI-H838 cells. PACAP-38 (31-38), human, mouse, rat acetate (100 nM; 30 min; NCI-H838 cells) induces EGFR tyrosine phosphorylation with generates ROS and increases ROS levels by 51%[3]. |
| Alias | PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base) |
| Molecular Weight | 1122.32 |
| Formula | C49H87N17O13 |
| Smiles | CC(O)=O.O=C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CC(N)=O)=O)=O)C(C)C)=O)CCCNC(N)=N)=O)=O)CCCCN)[C@@H](N)CC1=CC=C(O)C=C1 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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