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P11

Name: P11
Brand: TargetMol
SKU: T24586
Rating: 4.5 (1 reviews)

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Catalog No. T24586Cas No. 942285-55-4

Alias PAFAH-1-b-2, PAFAH1b2, PAFAH 1 b 2, 3-IN-P11, 3INP11, 3 IN P11

P11 is a selective platelet-activating factor acetylhydrolase (PAFAH1b2 and PAFAH1b3) inhibitor, blocking PAFAH1b2/3-mediated hydrolysis of PAF to lysophosphatidic acid, used to study PAFAH1b2/3 cellular functions.

P11

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Catalog No. T24586Alias PAFAH-1-b-2, PAFAH1b2, PAFAH 1 b 2, 3-IN-P11, 3INP11, 3 IN P11Cas No. 942285-55-4

Pack Size	Price	Availability
500 μg	$78	35 days
1 mg	$143	35 days
5 mg	$575	35 days
10 mg	$990	35 days

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	P11 is a selective platelet-activating factor acetylhydrolase (PAFAH1b2 and PAFAH1b3) inhibitor, blocking PAFAH1b2/3-mediated hydrolysis of PAF to lysophosphatidic acid, used to study PAFAH1b2/3 cellular functions.
Targets&IC50	PAFAH1b2:0.8 μM
In vitro	P11 showed particularly good efficacy against PAFAH1b2 with an IC50 value of 0.8 μM; P11 blocks the hydrolysis of PAFAH1b2 and Pafah1B3-mediated substrate PAF to hemolytic PAF with IC50 values of 36 and 880 nM, respectively. [1]
Alias	PAFAH-1-b-2, PAFAH1b2, PAFAH 1 b 2, 3-IN-P11, 3INP11, 3 IN P11

Chemical Properties

Molecular Weight	503.65
Formula	C₃₀H₃₃NO₄S
Cas No.	942285-55-4
Smiles	S(=O)(=O)(N1[C@H](C(C(O)=O)=CC[C@H]1C2=CC=C(C)C=C2)C3=CC=C(C(C)(C)C)C=C3)C4=CC=C(C)C=C4
Relative Density.	1.210 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 40 mg/mL (79.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9855 mL	9.9275 mL	19.8551 mL	99.2753 mL
5 mM	0.3971 mL	1.9855 mL	3.9710 mL	19.8551 mL
10 mM	0.1986 mL	0.9928 mL	1.9855 mL	9.9275 mL
20 mM	0.0993 mL	0.4964 mL	0.9928 mL	4.9638 mL
50 mM	0.0397 mL	0.1986 mL	0.3971 mL	1.9855 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PAFAH-1b2