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PD 123319 ditrifluoroacetate

Name: PD 123319 ditrifluoroacetate
Brand: TargetMol
SKU: T12381
Price: 83 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T12381Cas No. 136676-91-0

PD 123319 (ditrifluoroacetate) is a potent and selective AT2 angiotensin II receptor antagonist with an IC50 of 34 nM.

PD 123319 ditrifluoroacetate

Catalog No. T12381Cas No. 136676-91-0

PD 123319 (ditrifluoroacetate) is a potent and selective AT2 angiotensin II receptor antagonist with an IC50 of 34 nM.

Pack Size	Price	Availability	Quantity
200 mg	$995	7-10 days

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Product Introduction

Bioactivity

Description	PD 123319 (ditrifluoroacetate) is a potent and selective AT2 angiotensin II receptor antagonist with an IC50 of 34 nM.
Targets&IC50	AT2 receptor:34 nM
In vitro	PD-123319 did not have any effect on 125I-All binding to this site.?The second class of binding sites was more sensitive to PD-123319, with an IC50 of 6.9 +/- 3.7 nM, and had a much lower affinity for DuP-753 (IC50 around 10 microM).?The two classes of receptors had different affinities for All.?All showed an affinity around 2 nM for All type 1 receptor (AT1)(DuP-753 sensitive) and a higher affinity, around 0.3 nM, for All type 2 receptor (AT2) (PD-123319 sensitive).?All-induced steroidogenesis was completely abolished in the presence of 3 microM DuP-753, indicating that this activity was mediated through a DuP-753-sensitive receptor.

Chemical Properties

Molecular Weight	736.66
Formula	C₃₅H₃₄F₆N₄O₇
Cas No.	136676-91-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 36 mg/mL (48.87 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.3575 mL	6.7874 mL	13.5748 mL	67.8739 mL
5 mM	0.2715 mL	1.3575 mL	2.7150 mL	13.5748 mL
10 mM	0.1357 mL	0.6787 mL	1.3575 mL	6.7874 mL
20 mM	0.0679 mL	0.3394 mL	0.6787 mL	3.3937 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Keywords

PD 123319 DitrifluoroacetatePD123319 DitrifluoroacetatePD 123319 ditrifluoroacetatePD-123319PD 123319PD-123319 DitrifluoroacetatePD123319