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Pack Size | Price | Availability | Quantity |
---|---|---|---|
200 mg | $995 | 7-10 days |
Description | PD 123319 (ditrifluoroacetate) is a potent and selective AT2 angiotensin II receptor antagonist with an IC50 of 34 nM. |
In vitro | PD-123319 did not have any effect on 125I-All binding to this site.?The second class of binding sites was more sensitive to PD-123319, with an IC50 of 6.9 +/- 3.7 nM, and had a much lower affinity for DuP-753 (IC50 around 10 microM).?The two classes of receptors had different affinities for All.?All showed an affinity around 2 nM for All type 1 receptor (AT1)(DuP-753 sensitive) and a higher affinity, around 0.3 nM, for All type 2 receptor (AT2) (PD-123319 sensitive).?All-induced steroidogenesis was completely abolished in the presence of 3 microM DuP-753, indicating that this activity was mediated through a DuP-753-sensitive receptor. |
Molecular Weight | 736.66 |
Formula | C35H34F6N4O7 |
Cas No. | 136676-91-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | H2O: 36 mg/mL (48.87 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
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