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PD 123319
🥰Excellent
Catalog No. T6067Cas No. 130663-39-7
Alias PD123319, (S)-(+)-PD 123319
PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.
PD 123319
🥰Excellent
Purity: 98.75%
Catalog No. T6067Alias PD123319, (S)-(+)-PD 123319Cas No. 130663-39-7
PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $38 | In Stock | |
| 5 mg | $74 | In Stock | |
| 10 mg | $113 | In Stock | |
| 25 mg | $231 | In Stock | |
| 50 mg | $300 | In Stock | |
| 100 mg | $390 | In Stock | |
| 200 mg | $555 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $95 | In Stock |
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Purity:98.75%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist. |
| Targets&IC50 | AT2 receptor:34 nM |
| In vitro | Intravenous administration of PD 123319 to conscious hypertensive rats caused an immediate dose-dependent increase in MAP, and this effect was maintained for approximately 7.4 min with 3 mg/kg of PD 123319.PD 123319 had no effect on the self-regulation of cerebral blood flow. |
| In vivo | 125I-AII specifically labeled two classes of AII binding sites in bovine adrenal glomerular cell membrane preparations. The first class (DuP-753-sensitive) accounted for approximately 85% of the total AII binding sites and had a high affinity for DuP-753 (IC 50 of 92.9 nM).PD-123319 had no effect on the binding of 125I-AII to this site. The second type of binding site is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 of about 10 μM). |
| Alias | PD123319, (S)-(+)-PD 123319 |
| Molecular Weight | 508.61 |
| Formula | C31H32N4O3 |
| Cas No. | 130663-39-7 |
| Smiles | C(N1C2=C(CN(C(C(C3=CC=CC=C3)C4=CC=CC=C4)=O)[C@H](C(O)=O)C2)N=C1)C5=CC(C)=C(N(C)C)C=C5 |
| Relative Density. | 1.22 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (108.14 mM)  H2O: 196.6 mM | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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