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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $88 | 5 days | |
5 mg | $148 | 5 days | |
1 mL x 10 mM (in DMSO) | $178 | 5 days |
Description | PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor. |
In vitro | PF-05198007 (30 nM) blocks on average 83.0 ± 2.7% of the total TTX-S current. This shows the major TTX-S conductance is carried through Nav1.7 channels in small-diameter mouse DRG neurons (n = 35)[1]. |
In vivo | PF-05198007 (1 or 10 mg/kg, orally) decreases the capsaicin flare response in WT. However, it not reduces Nav1.7Nav1.8Cre mice[1]. |
Molecular Weight | 533.91 |
Formula | C19H12ClF4N5O3S2 |
Cas No. | 1235406-19-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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