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PIM-447 dihydrochloride

Name: PIM-447 dihydrochloride
Brand: TargetMol
SKU: T12473
Price: 68 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T12473Cas No. 1820565-69-2

Alias LGH447 dihydrochloride

PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).

PIM-447 dihydrochloride

Catalog No. T12473Alias LGH447 dihydrochlorideCas No. 1820565-69-2

PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).

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Product Introduction

Bioactivity

Description	PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).
Targets&IC50	Pim1:18 pM (Ki), Pim1:6 pM (Ki), Pim3:9 pM (Ki)
Alias	LGH447 dihydrochloride

Chemical Properties

Molecular Weight	513.38
Formula	C₂₄H₂₅Cl₂F₃N₄O
Cas No.	1820565-69-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 46.7 mg/mL (90.97 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9479 mL	9.7394 mL	19.4787 mL	97.3937 mL
5 mM	0.3896 mL	1.9479 mL	3.8957 mL	19.4787 mL
10 mM	0.1948 mL	0.9739 mL	1.9479 mL	9.7394 mL
20 mM	0.0974 mL	0.4870 mL	0.9739 mL	4.8697 mL
50 mM	0.0390 mL	0.1948 mL	0.3896 mL	1.9479 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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