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PIM447

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Catalog No. T12475Cas No. 1210608-43-7
Alias LGH447

PIM447 is a potent, orally available, and selective inhibitor of pan-PIM kinase(PIM1, PIM2, and PIM3 with Ki values of 6, 18, and 9 pM , respectively).

PIM447
Other Forms of PIM447:

PIM447

😃Good
Catalog No. T12475Alias LGH447Cas No. 1210608-43-7
PIM447 is a potent, orally available, and selective inhibitor of pan-PIM kinase(PIM1, PIM2, and PIM3 with Ki values of 6, 18, and 9 pM , respectively).
Pack SizePriceAvailabilityQuantity
1 mg$1,0908-10 weeks
5 mg$2,1908-10 weeks
10 mg$2,9508-10 weeks
25 mg$4,3808-10 weeks
50 mg$5,9208-10 weeks
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Product Introduction

Bioactivity
Description
PIM447 is a potent, orally available, and selective inhibitor of pan-PIM kinase(PIM1, PIM2, and PIM3 with Ki values of 6, 18, and 9 pM , respectively).
In vitro
PIM447 shows antiproliferative effect on the multiple myeloma (MM) cells,and induces apoptosis[2].
In vivo
PIM447 reduces tumor burden[2].
AliasLGH447
Chemical Properties
Molecular Weight440.46
FormulaC24H23F3N4O
Cas No.1210608-43-7
Relative Density.1.290 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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Keywords

LGH 447PIM 447PIM447PIM-447LGH-447
Related Tags: buy PIM447 | purchase PIM447 | PIM447 cost | order PIM447 | PIM447 chemical structure | PIM447 in vivo | PIM447 in vitro | PIM447 formula | PIM447 molecular weight
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