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Description | PIM447 is a potent, orally available, and selective inhibitor of pan-PIM kinase(PIM1, PIM2, and PIM3 with Ki values of 6, 18, and 9 pM , respectively). |
In vitro | PIM447 shows antiproliferative effect on the multiple myeloma (MM) cells,and induces apoptosis[2]. |
In vivo | PIM447 reduces tumor burden[2]. |
Alias | LGH447 |
Molecular Weight | 440.46 |
Formula | C24H23F3N4O |
Cas No. | 1210608-43-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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