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PIM447
🥰Excellent
Catalog No. T12475Cas No. 1210608-43-7
Alias PIM 447, LGH447, LGH 447
PIM447 (LGH447) is an oral, selective pan-PIM kinase inhibitor with antitumor and bone-protective effects. It inhibits PIM1, PIM2, and PIM3, induces apoptosis, and decreases the viability, proliferation, and motility of HuH6 and COA67 cells. PIM447 suppresses tumorigenesis in hepatocellular carcinoma and can be used in the study of multiple myeloma.
PIM447
🥰Excellent
Purity: 98.97%
Catalog No. T12475Alias PIM 447, LGH447, LGH 447Cas No. 1210608-43-7
PIM447 (LGH447) is an oral, selective pan-PIM kinase inhibitor with antitumor and bone-protective effects. It inhibits PIM1, PIM2, and PIM3, induces apoptosis, and decreases the viability, proliferation, and motility of HuH6 and COA67 cells. PIM447 suppresses tumorigenesis in hepatocellular carcinoma and can be used in the study of multiple myeloma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $118 | In Stock | |
| 5 mg | $293 | In Stock | |
| 10 mg | $478 | In Stock | |
| 25 mg | $767 | In Stock | |
| 50 mg | $987 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $323 | In Stock |
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Purity:98.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PIM447 (LGH447) is an oral, selective pan-PIM kinase inhibitor with antitumor and bone-protective effects. It inhibits PIM1, PIM2, and PIM3, induces apoptosis, and decreases the viability, proliferation, and motility of HuH6 and COA67 cells. PIM447 suppresses tumorigenesis in hepatocellular carcinoma and can be used in the study of multiple myeloma. |
| Targets&IC50 | Pim1:6 pM (Ki), Pim3:9 pM (Ki), Pim2:18 pM (Ki) |
| In vitro | HuH6 and COA67 cells were treated with PIM447 (0-20 μM, 72h), and the activity of PIM447 was significantly reduced with LD50 of 13 μM and 10 μM, respectively. Treatment with PIM447 (7.5 μM, 8h) resulted in increased apoptosis of HuH6 and COA67 cells. PIM447 (5 μM, 48h) reduced cancer cell dryness in HuH6 and COA67 cells. [1] |
| In vivo | PIM447 significantly reduced tumor load and prevented tumor-associated bone loss in a disseminated mouse model of human myeloma. [2] |
| Alias | PIM 447, LGH447, LGH 447 |
| Molecular Weight | 440.46 |
| Formula | C24H23F3N4O |
| Cas No. | 1210608-43-7 |
| Smiles | FC1=C(N=C(C(NC=2C(=CC=NC2)[C@@H]3C[C@H](C)C[C@H](N)C3)=O)C=C1)C4=C(F)C=CC=C4F |
| Relative Density. | 1.290 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (181.63 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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