PIP-199 is a selective inhibitor of the RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used to study DNA crosslink repair mechanisms and could serve as a sensitizing agent for chemoresistant tumors [1].

MM2, a peptide, serves as the binding site for the RMI complex on the Fanconi anemia complementation group M protein (FANCM) [1]. It plays a crucial role in activating the Fanconi anemia (FA) DNA repair pathway, which tumors commonly exploit to develop resistance to DNA crosslinking chemotherapies [1]. Effective operation of the FA pathway hinges on the interaction between FANCM and the RMI complex, with mutations impairing this interaction rendering cells more susceptible to DNA crosslinking agents [1].