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Pitolisant oxalate

Name: Pitolisant oxalate
Brand: TargetMol
SKU: T12491
Rating: 4.5 (1 reviews)

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Catalog No. T12491Cas No. 362665-57-4

Alias Tiprolisant oxalate

Pitolisant oxalate is a potent and selective nonimidazole inverse agonist of the recombinant human histamine H3 receptor, exhibiting a Ki of 0.16 nM.

Pitolisant oxalate

😃Good

Catalog No. T12491Alias Tiprolisant oxalateCas No. 362665-57-4

Pitolisant oxalate is a potent and selective nonimidazole inverse agonist of the recombinant human histamine H3 receptor, exhibiting a Ki of 0.16 nM.

Pack Size	Price	Availability
25 mg	$1,520	1-2 weeks
50 mg	$1,980	1-2 weeks
100 mg	$2,500	1-2 weeks

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Product Introduction

Bioactivity

Description	Pitolisant oxalate is a potent and selective nonimidazole inverse agonist of the recombinant human histamine H3 receptor, exhibiting a Ki of 0.16 nM.
Targets&IC50	H3 receptor:0.16 nM (Ki), H3 receptor:1.5 nM (EC50)
In vitro	Pitolisant behaves as a competitive antagonist with a Ki value of 0.16 nM and as an inverse agonist with an EC50 value of 1.5 nM and an intrinsic activity ~50% higher than that of ciproxifan.
In vivo	Administering Pitolisant at a single dose of 10 mg/kg 30 minutes before a 2 mg/kg b.w. dose of Olanzapine significantly affects immobility time in the FST. This drug sequence in mice significantly increases immobility duration compared to the control group in the FST and also decreases locomotor activity [3].
Alias	Tiprolisant oxalate

Chemical Properties

Molecular Weight	385.88
Formula	C₁₉H₂₈ClNO₅
Cas No.	362665-57-4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (129.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5915 mL	12.9574 mL	25.9148 mL	129.5740 mL
5 mM	0.5183 mL	2.5915 mL	5.1830 mL	25.9148 mL
10 mM	0.2591 mL	1.2957 mL	2.5915 mL	12.9574 mL
20 mM	0.1296 mL	0.6479 mL	1.2957 mL	6.4787 mL
50 mM	0.0518 mL	0.2591 mL	0.5183 mL	2.5915 mL
100 mM	0.0259 mL	0.1296 mL	0.2591 mL	1.2957 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Pitolisant oxalatePitolisant OxalateTiprolisant Oxalate