Shopping Cart
- Remove All
Your shopping cart is currently empty
Pitolisant
Catalog No. T60636Cas No. 362665-56-3
Alias Tiprolisant, BF-2649, BF-2.649
Pitolisant is a potent and selective nonimidazole inverse agonist that targets the recombinant human histamine H3 receptor, with a Ki of 0.16 nM.
Pitolisant
Catalog No. T60636Alias Tiprolisant, BF-2649, BF-2.649Cas No. 362665-56-3
Pitolisant is a potent and selective nonimidazole inverse agonist that targets the recombinant human histamine H3 receptor, with a Ki of 0.16 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $40 | In Stock | |
| 10 mg | $64 | In Stock | |
| 25 mg | $123 | In Stock | |
| 50 mg | $198 | In Stock | |
| 100 mg | $328 | In Stock | |
| 500 mg | $787 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Pitolisant"
Famotidine
MK-208
T162776824-35-6
Famotidine (MK-208) is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors on the basolateral membrane of parietal cells, famotidine reduces basal and nocturnal gastric acid secretion, thereby decreasing gastric volume, acidity, and the amount of gastric acid released in response to various stimuli.
- $50
Size
QTY
Meclizine dihydrochloride
NSC28728, Meclozine dihydrochloride, Meclizine 2HCl
T11101104-22-9
Meclizine dihydrochloride (NSC28728) is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
- $50
Size
QTY
Alginic acid
Snow acid algin G, Sazzio, Protanal LF, Norgine, Kelacid
T205979005-32-7
Alginic acid (Snow acid algin G) is a natural polysaccharide extracted from brown seaweeds with anti-anaphylactic and anti-inflammatory activities. Alginic acid inhibits histamine release and can be used in the food industry.
- $29
Size
QTY
Lidocaine
Xylocaine, Lignocaine, Alphacaine
T0468137-58-6
Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammatory cytokines, and reduction of neutrophils influx.
- $45
Size
QTY
Trazodone hydrochloride
Trazodone HCl, KB-831, AF-1161
T161925332-39-2
Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety.
- $39
Size
QTY
Mianserin hydrochloride
ORG GB-94 HCl, Org GB 94, Mianserin HCl
T078321535-47-7
Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant properties that blocks alpha-adrenergic, histamine H1, and certain serotonin receptors; it may cause drowsiness and hematological issues.
- $30
Size
QTY
Amitriptyline hydrochloride
Tryptizol, Domical, Annoyltin, Amitriptyline HCl
T0678549-18-8
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
5-HT ReceptorAChRAdrenergic ReceptorHistamine ReceptorNorepinephrineSerotonin TransporterSigma receptorSodium ChannelTrk receptor
- $45
Size
QTY
Sodium butanoate
Sodium Butyrate, Butanoic acid sodium salt
T1393156-54-7
Sodium butanoate (Sodium Butyrate) is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).
- $33
Size
QTY
Mirtazapine
Org3770, 6-Azamianserin
T013785650-52-8
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
- $34
Size
QTY
Mebhydrolin napadisylate
Omeril, Mebhydroline 1,5-naphthalenedisulfonate salt, Incidal, Diazoline, Diazolin
T01136153-33-9
Mebhydrolin napadisylate (Incidal) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
- $39
Size
QTY
Chlorphenesin
Gecophen, Chlorophenesin, Adermykon
T4507104-29-0
Chlorphenesin (Chlorophenesin) is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent.
- $37
Size
QTY
Nizatidine
Zanizal, Axid, Acinon
T157576963-41-2
Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
- $29
Size
QTY
Select Batch
Purity:99.84%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Pitolisant is a potent and selective nonimidazole inverse agonist that targets the recombinant human histamine H3 receptor, with a Ki of 0.16 nM. |
| Targets&IC50 | H3 receptor:1.5 nM (EC50), H3 receptor:0.16 nM (Ki) |
| In vitro | When stimulating [35S]-thiophosphate-labeled GTPγS binding to recombinant human H3 receptors, Pitolisant (BF2.649) acts as a competitive antagonist with a Ki value of 0.16 nM. As a reverse agonist, its EC50 value is 1.5 nM, with intrinsic activity about 50% higher than that of ciproxifan[1]. |
| In vivo | Pitolisant (BF2.649) dose-dependently enhances histamine levels in the mouse brain, with an ED50 value of 1.6 mg/kg p.o. This effect persists after repeated administration for 17 days[1]. |
| Alias | Tiprolisant, BF-2649, BF-2.649 |
| Molecular Weight | 295.85 |
| Formula | C17H26ClNO |
| Cas No. | 362665-56-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (270.41 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Pitolisant | purchase Pitolisant | Pitolisant cost | order Pitolisant | Pitolisant chemical structure | Pitolisant in vivo | Pitolisant in vitro | Pitolisant formula | Pitolisant molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.