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Pramlintide acetate(151126-32-8 free base)

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Catalog No. TP2320Cas No. 187887-46-3

Pramlintide acetate, a polypeptide analogue of human amylin, functions as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer.

Pramlintide acetate(151126-32-8 free base)
Other Forms of Pramlintide acetate(151126-32-8 free base):

Pramlintide acetate(151126-32-8 free base)

🥰Excellent
Purity: 100%
Catalog No. TP2320Cas No. 187887-46-3
Pramlintide acetate, a polypeptide analogue of human amylin, functions as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer.
Pack SizePriceAvailabilityQuantity
1 mg$36In Stock
5 mg$88In Stock
10 mg$137In Stock
25 mg$298In Stock
50 mg$433In Stock
100 mg$592In Stock
200 mg$783In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Pramlintide acetate, a polypeptide analogue of human amylin, functions as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer.
In vitro
Pramlintide inhibited the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC50s; 48.67 and 9.10 μg/mL, respectively;?p-value =0.013). Moreover, the addition of 5, 10, and 20 μg/mL of pramlintide to HCT-116 and HT-29 with 5-fluorouracil, oxaliplatin, or irinotecan induced the antiproliferative effect synergistically (R>1.6,?p-value <0.05).
Chemical Properties
Molecular Weight4009
FormulaC173H271N51O55S2
Cas No.187887-46-3
SmilesCC[C@@H]([C@H](NC([C@@H]1CCCN1C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CSSC[C@H](NC([C@@H](N)CCCCN)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N2)=O)=O)=O)=O)=O)=O)C)=O)[C@H](O)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)C)=O)CC(N)=O)=O)CC3=CC=CC=C3)=O)CC(C)C)=O)C(C)C)=O)CC4=CNC=N4)=O)CO)=O)CO)=O)CC(N)=O)=O)CC(N)=O)=O)CC5=CC=CC=C5)=O)=O)=O)C(N[C@H](C(N6CCC[C@H]6C(N7CCC[C@H]7C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC8=CC=C(O)C=C8)=O)[C@H](O)C)=O)CC(N)=O)=O)CO)=O)=O)C(C)C)=O)CC(N)=O)=O)[C@H](O)C)=O)=O)=O)CC(C)C)=O)C.CC(O)=O
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mM
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.2494 mL1.2472 mL2.4944 mL12.4719 mL
5 mM0.0499 mL0.2494 mL0.4989 mL2.4944 mL
10 mM0.0249 mL0.1247 mL0.2494 mL1.2472 mL

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Keywords

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