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Prodigiosin hydrochloride

Catalog No. T40643 CAS 56144-17-3

Synonyms: Prodigiosine hydrochloride

Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this compound possesses antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties.

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Prodigiosin hydrochloride Chemical Structure

Prodigiosin hydrochloride, CAS 56144-17-3

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Biological Description

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Storage & Solubility Information

Description	Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this compound possesses antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties.
In vitro	Treatment with Prodigiosin (25-500 nM) for 24 hours significantly reduces the viability and proliferation of breast cancer cells, specifically demonstrating IC50 values of 62.52 nM in MDA-MB-231 cells and 261.2 nM in MDA-MB-468 cells after 48 hours. Furthermore, this treatment markedly diminishes the levels of crucial components in the Wnt signaling pathway, namely phosphorylated LRP6, DVL2, active and total β-catenin in cell line studies, while also enhancing GSK3β activity through reduced phosphorylation at Ser9 in HEK293T cells. These effects suggest a potent inhibition of cell proliferation and induction of apoptosis in breast cancer cells, as well as a dose-dependent blockage of Wnt signaling stimulated by various Wnt factors in transfected HEK293T cells. Additionally, Prodigiosin exhibits significant antifungal activity against chytrid fungi, Batrachochytrium dendrobatidis, and B. salamandrivorans, with MIC values of 10 μM and 50 μM, respectively. These findings underscore Prodigiosin's broad biological activity, including its ability to inhibit Wnt signaling and its potential therapeutic applications in cancer and fungal infections.
In vivo	Prodigiosin (5 mg/kg; intraperitoneal injection; twice weekly; for 3 weeks) significantly inhibits tumor growth by reducing tumor cell density and decreasing the expression of the proliferation marker Ki-67[1] in an animal model comprising female BALB/c nude mice injected with MDA-MB-231 cells[1]. This treatment schedule resulted in a marked inhibition of tumor growth in mice.

Synonyms	Prodigiosine hydrochloride
Molecular Weight	359.9
Formula	C20H26ClN3O
CAS No.	56144-17-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wang Z, et al. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13150-13155. 2. Woodhams DC, et al. Prodigiosin, Violacein, and Volatile Organic Compounds Produced by Widespread Cutaneous Bacteria of Amphibians Can Inhibit Two Batrachochytrium Fungal Pathogens. Microb Ecol. 2018 May;75(4):1049-1062.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Prodigiosin hydrochloride 56144-17-3 Prodigiosin Hydrochloride Prodigiosine hydrochloride Prodigiosine Hydrochloride inhibitor inhibit

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