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PROTAC BRD4-binding moiety 1

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Catalog No. T18599Cas No. 2101200-10-4

PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand via a linker, facilitating the formation of a PROTAC complex which efficiently degrades BRD4[1].

PROTAC BRD4-binding moiety 1

PROTAC BRD4-binding moiety 1

😃Good
Catalog No. T18599Cas No. 2101200-10-4
PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand via a linker, facilitating the formation of a PROTAC complex which efficiently degrades BRD4[1].
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Product Introduction

Bioactivity
Description
PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand via a linker, facilitating the formation of a PROTAC complex which efficiently degrades BRD4[1].
In vitro
PROTAC BRD4 Degrader-2 is an effective PROTAC BRD4 degrader, exhibiting an IC50 of 14.2 nM against BRD4 BD1 [1].
Chemical Properties
Molecular Weight371.43
FormulaC23H21N3O2
Cas No.2101200-10-4
Relative Density.1.195 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

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