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PSEN1-IN-1

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Catalog No. T79679

PSEN1-IN-1 (Compound (+)-13b) is an inhibitor of PSEN1, exhibiting strong inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with IC50 values of 19 nM and 5.5 nM, respectively. It is employed in Alzheimer's disease research [1].

PSEN1-IN-1

PSEN1-IN-1

😃Good
Catalog No. T79679
PSEN1-IN-1 (Compound (+)-13b) is an inhibitor of PSEN1, exhibiting strong inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with IC50 values of 19 nM and 5.5 nM, respectively. It is employed in Alzheimer's disease research [1].
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Product Introduction

Bioactivity
Description
PSEN1-IN-1 (Compound (+)-13b) is an inhibitor of PSEN1, exhibiting strong inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with IC50 values of 19 nM and 5.5 nM, respectively. It is employed in Alzheimer's disease research [1].
Chemical Properties
Molecular Weight445.88
FormulaC20H19ClF3NO3S
Storage & Solubility Information
StorageShipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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