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PSMA-D5

Name: PSMA-D5
Brand: TargetMol
SKU: T203023
Rating: 4.5 (1 reviews)

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Catalog No. T203023Cas No. 3056440-83-3

PSMA-D5 exhibits a binding affinity for PSMA with a Ki of 0.21 nM and becomes useful for PSMA tracing following radiolabeling. When marked with [68Ga], PSMA-D5 contains a DOTA chelator, facilitating the convenient labeling with therapeutic radionuclides such as 177Lu and 225Ac. Additionally, [68Ga]-labeled PSMA-D5 demonstrates exceptional pharmacokinetic properties and significant tumor uptake in 22Rv1 tumors. This compound can be employed in the synthesis and research of radiolabeled conjugates (RDC).

PSMA-D5

😃Good

Catalog No. T203023Cas No. 3056440-83-3

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Product Introduction

Bioactivity

Description	PSMA-D5 exhibits a binding affinity for PSMA with a Ki of 0.21 nM and becomes useful for PSMA tracing following radiolabeling. When marked with [68Ga], PSMA-D5 contains a DOTA chelator, facilitating the convenient labeling with therapeutic radionuclides such as 177Lu and 225Ac. Additionally, [68Ga]-labeled PSMA-D5 demonstrates exceptional pharmacokinetic properties and significant tumor uptake in 22Rv1 tumors. This compound can be employed in the synthesis and research of radiolabeled conjugates (RDC).
In vitro	PSMA-D5 ([68 Ga] labeled) demonstrates excellent uptake performance in PSMA-positive 22Rv1 cells, with an uptake value of 1.68.
In vivo	PSMA-D5 ([68 Ga] labeled), administered at approximately 3.7 MBq via intravenous injection, exhibits a high tumor uptake in 22Rv1 tumors (SUV max = 3.51). Compared to PSMA-11 ([68 Ga] labeled), it demonstrates improved visualization of smaller lesions, with T/M values of 32.01 and 26.8, respectively.

Chemical Properties

Molecular Weight	1317.31
Formula	C₅₇H₈₀N₁₂O₂₄
Cas No.	3056440-83-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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