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DUPA(OtBu)-OH

DUPA(OtBu)-OH is a precursor of DUPA, which is used as a targeting moiety to actively deliver Docetaxel (DTX) for treating Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer, with PSMA showing high affinity for DUPA (Ki = 8 nM).

Catalog No. T11122Cas No. 1026987-94-9

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Purity:99.74%

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COA HNMR HPLC

DUPA(OtBu)-OH

Catalog No. T11122Cas No. 1026987-94-9

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Pack Size	Price	Availability
1 mg	$48	In Stock
2 mg	$68	In Stock
5 mg	$113	In Stock
10 mg	$189	In Stock
25 mg	$313	In Stock
50 mg	$438	In Stock
100 mg	$619	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Product Introduction

Bioactivity

Description	DUPA(OtBu)-OH is a precursor of DUPA, which is used as a targeting moiety to actively deliver Docetaxel (DTX) for treating Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer, with PSMA showing high affinity for DUPA (Ki = 8 nM).
In vitro	DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis.
In vivo	Histological analysis indicated that DUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice.

Chemical Properties

Molecular Weight	488.57
Formula	C₂₃H₄₀N₂O₉
Cas No.	1026987-94-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (255.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0468 mL	10.2339 mL	20.4679 mL	102.3395 mL
5 mM	0.4094 mL	2.0468 mL	4.0936 mL	20.4679 mL
10 mM	0.2047 mL	1.0234 mL	2.0468 mL	10.2339 mL
20 mM	0.1023 mL	0.5117 mL	1.0234 mL	5.1170 mL
50 mM	0.0409 mL	0.2047 mL	0.4094 mL	2.0468 mL
100 mM	0.0205 mL	0.1023 mL	0.2047 mL	1.0234 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorDUPA(OtBu)-OHDUPA(OtBu)OHDUPA(OtBu) OHinhibit