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Razaxaban hydrochloride

Name: Razaxaban hydrochloride
Brand: TargetMol
SKU: T12694
Rating: 4.5 (1 reviews)

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Catalog No. T12694Cas No. 405940-76-3

Alias DPC 906 hydrochloride, BMS 561389 hydrochloride

Razaxaban hydrochloride is a highly potent, selective and orally active inhibitor of factor Xa(Ki of 0.19 nM),has strongly antithrombotic activity.

Razaxaban hydrochloride

😃Good

Catalog No. T12694Alias DPC 906 hydrochloride, BMS 561389 hydrochlorideCas No. 405940-76-3

Razaxaban hydrochloride is a highly potent, selective and orally active inhibitor of factor Xa(Ki of 0.19 nM),has strongly antithrombotic activity.

Pack Size	Price	Availability
25 mg	$1,670	6-8 weeks
50 mg	$2,180	6-8 weeks
100 mg	$2,800	6-8 weeks

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Product Introduction

Bioactivity

Description	Razaxaban hydrochloride is a highly potent, selective and orally active inhibitor of factor Xa(Ki of 0.19 nM),has strongly antithrombotic activity.
Targets&IC50	Thrombin: 540 nM (ki), FXa:ki:0.19 nM
In vitro	Razaxaban shows good Caco-2 permeability. The anticoagulant activity of Razaxaban is evaluated in the in vitro human plasma activated partial thromboplastin time (aPTT) and human prothrombin time (PT) assays. Razaxaban shows a doubling of aPTT and PT at 6.1 μM and 2.1 μM, respectively. .
In vivo	Traetment with Razaxaban inhibits thrombus formation in a dose-dependent manner (ID50 of 1.6 μmol/kg/h in the rabbit arterio-venous shunt thrombosis model).
Alias	DPC 906 hydrochloride, BMS 561389 hydrochloride

Chemical Properties

Molecular Weight	564.92
Formula	C₂₄H₂₁ClF₄N₈O₂
Cas No.	405940-76-3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ThrombinRazaxaban HydrochlorideRazaxaban hydrochlorideFactor XaDPC-906 HydrochlorideDPC906 HydrochlorideDPC 906 HydrochlorideBMS-561389 HydrochlorideBMS561389 HydrochlorideBMS 561389 Hydrochloride