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Search Results for " thrombin "

Targets

194

Compounds

12

Natural Products

53

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T9845 Thrombin inhibitor 5
Thrombin inhibitor 5 (compound 385) is a thrombin inhibitor with IC 50s ranging from 0.1 μM to 1 μM. Thrombin inhibitor 5 can be used for venous thromboembolism research[1].
T7674 Thrombin Receptor Activator for Peptide Protease-activated Receptor
Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).
T19580 Thrombin (MW 37kDa) Thrombin Thrombin
Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.
T10081 Thrombin inhibitor 1 Thrombin
Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).
T7496 Thrombin Receptor Activator for Peptide 5 (TRAP-5) Thrombin Receptor Activator for Peptide Protease-activated Receptor
Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).
T36777 Thrombin Receptor Agonist Peptide (trifluoroacetate salt)
Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor. It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma. TRAP-14 (100 μM) ...
T36553 Thrombin Receptor Peptide Ligand (trifluoroacetate salt)
Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 μM to inhibit platelet aggregation in vitro). It inhibits α-thrombin and platelet aggregation induced by thrombin receptor activating...
T17091 Thrombin Inhibitor 2 Others
Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor. Thrombin Inhibitor 2 has antithrombotic activity.
T7625 TRAP-6 PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA) Protease-activated Receptor
TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
T72448 Thrombin inhibitor 6
Thrombin inhibitor 6 is a potent thrombin inhibitor ( IC 50 : 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant .
TP2234 Coagulation factor II (thrombin) B chain fragment [Homo sapiens] Others
Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a ser...
T80512 Thrombin receptor peptide ligand Thrombin
Thrombin receptor peptide ligand, a thrombin receptor antagonist, serves as an antithrombotic agent [1].
T3757 NQ301 Thrombin , Platelet aggregation
NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).
T1986 Atopaxar E5555,ER-172594-00 Protease-activated Receptor
Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.
T12870 SCH79797 dihydrochloride Apoptosis , Others , Protease-activated Receptor
SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.
T7137 I-191 Protease-activated Receptor
I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.
TQ0012 AZ3451 Protease-activated Receptor
AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
T6594 MNS Syk , Src , p97
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
T2370 AC-55541 AOB2796 Proteasome , Protease-activated Receptor
AC-55541 (AOB2796) is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.
T6295 Dabigatran BIBR 953,BIBR 953ZW Thrombin
Dabigatran (BIBR 953ZW) is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients...
T22246 Argatroban Monohydrate Thrombin
Argatroban Monohydrate is a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
TP1046 SLIGRL-NH2 Protease-Activated Receptor-2 Activating Peptide Protease-activated Receptor
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a protease-activated receptor-2 (PAR-2) agonist that induces non-histaminergic pruritus.
T6370 AEBSF hydrochloride AEBSF HCl,Pefabloc SC Thrombin , Serine Protease , Influenza Virus
AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.
T0155 Argatroban MCI-9038,MD-805,Argipidine Thrombin
Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
T5519 Bivalirudin BG-8967,Hirulog-1 Thrombin
Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.
T0389 Dabigatran etexilate BIBR 1048 Thrombin
Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.
T7013 Vorapaxar SCH 530348,MK-5348 Protease-activated Receptor
Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).
T1893 Parmodulin 2 ML 161 Protease-activated Receptor
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thromb...
T22323 Enoxaparin sodium Thrombin
Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percu...
T5133 Dabigatran Etexilate Mesylate BIBR 1048MS,Dabigatran etexilate methanesulfonate Thrombin
Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).
T17265 Ximelagatran EXANTA,H 376-95,H37695,H 376/95,H-37695,H 37695 Thrombin
Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo.
T8917 PAR-2-IN-1 IUN76750 Protease-activated Receptor
PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
T3098 Vorapaxar sulfate SCH 530348 sulfate,Zontivity,vorapaxar monosulfate Protease-activated Receptor
Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.
TP1065 PAR-4 Agonist Peptide, amide TFA PAR-4-AP (TFA),AY-NH2 (TFA) Protease-activated Receptor
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.
T1986L Atopaxar Hydrobromide Protease-activated Receptor
Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.
T10951 Dabigatran ethyl ester hydrochloride Others , Thrombin
Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.
T7513 Protease-Activated Receptor-2, amide SLIGKV-NH2 Protease-activated Receptor
Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)
T7623 PAR-4 Agonist Peptide, amide AY-NH2,PAR-4 Agonist Peptide, amide(2TFA),PAR-4-AP Protease-activated Receptor
PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).
T2368 Edoxaban Tosylate Monohydrate DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban Factor Xa , Thrombin
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
T4186 AC-264613 AC264613 Protease-activated Receptor
AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613(AC264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macropha...
T40711 H-D-Phe-Pip-Arg-pNA dihydrochloride S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride Others
H-D-Phe-Pip-Arg-pNA dihydrochloride, a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, H-D-Phe-Pip...
T7573 TFLLR-NH2 TFLLR-NH2(2TFA) Protease-activated Receptor
TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
T7380 Protease-Activated Receptor-4 Protease-activated Receptor
Protease-Activated Receptor-4 is the proteinase-activated receptor-4 (PAR4) agonist, with Antiplatelet Therapy
T22676 Prothrombin (474-477) [Mus musculus] Others
Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothro...
T9892 JAMM protein inhibitor 2  Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]- Others
JAMM protein inhibitor 2 (Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-) is an inhibitor of JAMM protease and can be used for anticancer studies. The IC50s are 10 μM, 46 μM, and 89 μM for thrombin,...
T36951 N-(p-Tosyl)-GPR-pNA acetate Others
N-(p-Tosyl)-GPR-pNA acetate is a colorimetric substrate for thrombin that can act as a measure of thrombin activity.
T8362 Benzamidine hydrochloride Benzamidine HCl Serine/threonin kinase , Serine Protease
Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).
T25364L Efegatran sulfate LY294468 sulfate,GYKI-14766 sulfate,LY 294468 sulfate,LY-294468 sulfate Thrombin
Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.
T11994 Melagatran Thrombin
Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzymes in the coagulation cascade or fibrinolytic enzymes. It does not rely on endogenous co-factors to e...
T37034 H-Gly-Arg-pNA dihydrochloride H-Gly-Arg-Pna 2HCl
H-Gly-Arg-pNA dihydrochloride (H-Gly-Arg-Pna 2HCl) belongs to the class of peptides that bind to 1,2 thrombin and can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity.

Compounds

Thrombin inhibitor 5
T9845
Synonym:
Target:
Thrombin Receptor Activator for Peptide
T7674
Synonym:
Target: Protease-activated Receptor
Thrombin (MW 37kDa)
T19580
Synonym: Thrombin
Target: Thrombin
Thrombin inhibitor 1
T10081
Synonym:
Target: Thrombin
Thrombin Receptor Activator for Peptide 5 (TRAP-5)
T7496
Synonym: Thrombin Receptor Activator for Peptide
Target: Protease-activated Receptor
Thrombin Receptor Agonist Peptide (trifluoroacetate salt)
T36777
Synonym:
Target:
Thrombin Receptor Peptide Ligand (trifluoroacetate salt)
T36553
Synonym:
Target:
Thrombin Inhibitor 2
T17091
Synonym:
Target: Others
TRAP-6
T7625
Synonym: PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA)
Target: Protease-activated Receptor
Thrombin inhibitor 6
T72448
Synonym:
Target:
coagulation factor II (thrombin) B chain fragment [Homo sapiens]
TP2234
Synonym:
Target: Others
Thrombin receptor peptide ligand
T80512
Synonym:
Target: Thrombin
NQ301
T3757
Synonym:
Target: Thrombin, Platelet aggregation
Atopaxar
T1986
Synonym: E5555,ER-172594-00
Target: Protease-activated Receptor
SCH79797 dihydrochloride
T12870
Synonym:
Target: Apoptosis, Others, Protease-activated Receptor
I-191
T7137
Synonym:
Target: Protease-activated Receptor
AZ3451
TQ0012
Synonym:
Target: Protease-activated Receptor
MNS
T6594
Synonym:
Target: Syk, Src, p97
AC-55541
T2370
Synonym: AOB2796
Target: Proteasome, Protease-activated Receptor
Dabigatran
T6295
Synonym: BIBR 953,BIBR 953ZW
Target: Thrombin
Argatroban Monohydrate
T22246
Synonym:
Target: Thrombin
SLIGRL-NH2
TP1046
Synonym: Protease-Activated Receptor-2 Activating Peptide
Target: Protease-activated Receptor
AEBSF hydrochloride
T6370
Synonym: AEBSF HCl,Pefabloc SC
Target: Thrombin, Serine Protease, Influenza Virus
Argatroban
T0155
Synonym: MCI-9038,MD-805,Argipidine
Target: Thrombin
Bivalirudin
T5519
Synonym: BG-8967,Hirulog-1
Target: Thrombin
Dabigatran etexilate
T0389
Synonym: BIBR 1048
Target: Thrombin
Vorapaxar
T7013
Synonym: SCH 530348,MK-5348
Target: Protease-activated Receptor
Parmodulin 2
T1893
Synonym: ML 161
Target: Protease-activated Receptor
Enoxaparin sodium
T22323
Synonym:
Target: Thrombin
Dabigatran Etexilate Mesylate
T5133
Synonym: BIBR 1048MS,Dabigatran etexilate methanesulfonate
Target: Thrombin
Ximelagatran
T17265
Synonym: EXANTA,H 376-95,H37695,H 376/95,H-37695,H 37695
Target: Thrombin
PAR-2-IN-1
T8917
Synonym: IUN76750
Target: Protease-activated Receptor
Vorapaxar sulfate
T3098
Synonym: SCH 530348 sulfate,Zontivity,vorapaxar monosulfate
Target: Protease-activated Receptor
PAR-4 Agonist Peptide, amide TFA
TP1065
Synonym: PAR-4-AP (TFA),AY-NH2 (TFA)
Target: Protease-activated Receptor
Atopaxar Hydrobromide
T1986L
Synonym:
Target: Protease-activated Receptor
Dabigatran ethyl ester hydrochloride
T10951
Synonym:
Target: Others, Thrombin
Protease-Activated Receptor-2, amide
T7513
Synonym: SLIGKV-NH2
Target: Protease-activated Receptor
PAR-4 Agonist Peptide, amide
T7623
Synonym: AY-NH2,PAR-4 Agonist Peptide, amide(2TFA),PAR-4-AP
Target: Protease-activated Receptor
Edoxaban Tosylate Monohydrate
T2368
Synonym: DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban
Target: Factor Xa, Thrombin
AC-264613
T4186
Synonym: AC264613
Target: Protease-activated Receptor
H-D-Phe-Pip-Arg-pNA dihydrochloride
T40711
Synonym: S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride
Target: Others
TFLLR-NH2
T7573
Synonym: TFLLR-NH2(2TFA)
Target: Protease-activated Receptor
Protease-Activated Receptor-4
T7380
Synonym:
Target: Protease-activated Receptor
Prothrombin (474-477) [Mus musculus]
T22676
Synonym:
Target: Others
JAMM protein inhibitor 2 
T9892
Synonym: Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-
Target: Others
N-(p-Tosyl)-GPR-pNA acetate
T36951
Synonym:
Target: Others
Benzamidine hydrochloride
T8362
Synonym: Benzamidine HCl
Target: Serine/threonin kinase, Serine Protease
Efegatran sulfate
T25364L
Synonym: LY294468 sulfate,GYKI-14766 sulfate,LY 294468 sulfate,LY-294468 sulfate
Target: Thrombin
Melagatran
T11994
Synonym:
Target: Thrombin
H-Gly-Arg-pNA dihydrochloride
T37034
Synonym: H-Gly-Arg-Pna 2HCl
Target:
1 2 3 4
Cat No. Product Name Synonyms Targets
T3839 Cycloolivil Isoolivil Free radical scavengers , Others , Platelet aggregation
Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees. Cycloolivil has antioxidant activity, it may prevent thrombotic complications associated t...
TN3831 (-)-Denudatin B Denudatin B ATPase , Potassium Channel , Calcium Channel , PAFR
(-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin.
TN1054 Loureirin C Others
Loureirin C can inhibit the activities of thrombin in vitro effectively.
T3781 Jujuboside B Others
Jujuboside B has potent inhibitory effects on collagen-, thrombin-, AA-, and ADP-induced aggregation, and also exhibits superior protection on the thromboembolic model.
T3S0601 Buddlejasaponin IVb Saikosaponin 1b Others
1. Buddlejasaponin IVb (Saikosaponin 1b)(200 uM) can shorten thrombin time (TT) by 20.6 %, suggests that it has hemostasis efficacy.
T3793 (20R)-Ginsenoside Rh1 20(R)-Ginsenoside Rh1 Others
(20R)-Ginsenoside Rh1 (20(R)-Ginsenoside Rh1) can inhibit the thrombin-induced conversion of fibrinogen to fibrin.
T5S0896 Loureirin A Akt , PI3K
Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept...
T5S2358 Dehydrocorydaline Dehydrocorydalin,13-Methylpalmatine BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...
TN4917 Rosenonolactone Others
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin.
T36532 SCH 38519
SCH 38519 is an isochromanequinone fungal metabolite originally isolated from Thermomonospora. It inhibits aggregation induced by thrombin , as well as inhibits serotonin secretion in human platelets (IC50s = 68 and 61 μ...
TN4860 Pueroside B COX , PPAR
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A rece...
TN6014 Norcepharadione B
Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-05025 Thrombin Receptor Protein, Human, Recombinant (His) Human HEK293
TMPY-04996 Coagulation Factor II Protein, Rat, Recombinant (His) Rat HEK293
Coagulation Factor II Protein (FII, F2 Protein or Prothrombin) is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Coagulation ...
TMPY-01791 Coagulation Factor II Protein, Mouse, Recombinant (His) Mouse HEK293
Coagulation Factor II Protein (FII, F2 Protein or Prothrombin) is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Coagulation ...
TMPH-00038 Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc) Agkistrodon contortrix E. coli
TMPJ-00649 CPB2 Protein, Human, Recombinant (His) Human Human Cells
Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the pl...
TMPJ-00243 Serpin B6 Protein, Human, Recombinant (E. coli, His) Human E. coli
Serpin B6 belongs to the serpin family. Serpin B6 localizes to the cytoplasm. Serpin B6 is expressed in many tissues, abundantly by mast cells in different tissues and mastocytoma lesions. Serpin B6 may be involved in th...
TMPY-00916 Antithrombin III Protein, Human, Recombinant (His) Human HEK293
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prog...
TMPY-02471 Antithrombin III Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prog...
TMPH-01974 Prothrombin Protein, Human, Recombinant (His) Human Yeast
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.
TMPH-01975 Prothrombin Protein, Human, Recombinant (His & SUMO) Human E. coli
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
TMPY-01101 Coagulation factor X/F10 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the...
TMPY-02185 Coagulation factor XIII B/F13B Protein, Human, Recombinant (His) Human HEK293
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ...
TMPY-01278 Apolipoprotein H/APOH Protein, Human, Recombinant (His) Human HEK293
Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipop...
TMPY-01254 Serpin D1 Protein, Mouse, Recombinant (His) Mouse HEK293
SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibiti...
TMPY-03271 Thrombomodulin Protein, Rat, Recombinant (His) Rat HEK293
Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the ...
TMPY-00917 Serpin D1 Protein, Human, Recombinant (His) Human HEK293
SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibiti...
TMPY-05829 Thrombomodulin Protein, Human, Recombinant (His) Human HEK293
Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the ...
TMPY-01631 Carboxypeptidase B2 Protein, Human, Recombinant (His) Human HEK293
Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are en...
TMPY-02505 Carboxypeptidase B2 Protein, Mouse, Recombinant (His) Mouse HEK293
Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are en...
TMPY-04490 Carboxypeptidase B2 Protein, Rat, Recombinant (His) Rat HEK293
Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are en...
TMPH-00706 MppA Protein, E. coli, Recombinant (His & SUMO) E. coli E. coli
Thrombin-like snake venom serine protease. Has a coagulant activity. Acts on alpha-chains of fibrinogen (FGA) generating fibrinopeptide A.
TMPH-00998 CD147 Protein, Human, Recombinant (aa 138-323, hFc) Human HEK293
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
TMPJ-00452 Serpin A1a Protein, Mouse, Recombinant (His) Mouse Human Cells
Serpin A1a is also known as alpha-1-antitrypsin, is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Its primary target is elast...
TMPH-01419 RAN Protein, Human, Recombinant (GST) Human E. coli
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT...
TMPH-01420 SAR1A Protein, Human, Recombinant (GST) Human E. coli
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT...
TMPJ-00796 Serpin E2 Protein, Human, Recombinant (His) Human Human Cells
Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal panc...
TMPK-01043 VEGFC Protein, Human, Recombinant (His & Avi) Human HEK293
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet...
TMPK-01044 VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet...
TMPJ-00490 Serpin A5 Protein, Human, Recombinant (His) Human Human Cells
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent i...
TMPH-02846 BICD2 Protein, Mouse, Recombinant (GST) Mouse E. coli
Thrombin-like snake venom serine protease that clots fibrinogen (FGA) by releasing fibrinopeptide A. According to PubMed:8585090, only cleaves rabbit fibrinogen, whereas no specificity is described in PubMed:3910643 (tes...
TMPH-00999 BCL6 Protein, Human, Recombinant (His) Human E. coli
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor pro...
TMPJ-01069 Serpin A1e Protein, Mouse, Recombinant (His) Mouse Human Cells
Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-...
TMPJ-00605 GPVI Protein, Mouse, Recombinant (His) Mouse Human Cells
Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregat...
TMPY-02242 Serpin B6 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-...
TMPJ-01124 PDIA6 Protein, Human, Recombinant (His) Human Human Cells
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and br...
TMPJ-01282 Serpin B12 Protein, Human, Recombinant (His) Human Human Cells
Serpin B12 is a member of the serpin family. Serpins are the largest and most diverse family of serine protease inhibitors. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular f...
TMPY-03604 VAMP3 Protein, Human, Recombinant (His) Human E. coli
VAMP3, also known as cellubrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components...
TMPY-01718 Serpin B12 Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl...
TMPJ-00505 Serpin A1 Protein, Human, Recombinant (aa 25-418, His) Human Human Cells
Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent,...
TMPJ-00707 Coagulation factor X/F10 Protein, Mouse, Recombinant (His) Mouse Human Cells
Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin ...
TMPJ-00301 Coagulation Factor X Protein, Human, Recombinant (hFc) Human Human Cells
F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways a...
TMPJ-00193 TREML1 Protein, Human, Recombinant (hFc) Human Human Cells
Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-...
TMPJ-01083 Serpin E2 Protein, Mouse, Recombinant (His) Mouse Human Cells
Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice lea...
TMPJ-00857 Thrombomodulin Protein, Mouse, Recombinant (His) Mouse Human Cells
Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a matu...
TMPJ-00734 KNG1 Protein, Human, Recombinant (His) Human Human Cells
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role ...
TMPY-02628 Neuroserpin Protein, Mouse, Recombinant (His) Mouse HEK293
Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not ...
TMPY-00821 HGFA Protein (pro form), Human, Recombinant (His) Human HEK293
HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the act...
TMPY-01241 Neuroserpin Protein, Human, Recombinant (His) Human HEK293
Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not ...
TMPJ-00535 F13A Protein, Human, Recombinant (His) Human Human Cells
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, ...
TMPY-01840 TLT-1/TREML1 Protein, Human, Recombinant (His) Human HEK293
Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusive...
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Thrombin Receptor Protein, Human, Recombinant (His)
TMPY-05025
Species: Human
Expression System: HEK293
Coagulation Factor II Protein, Rat, Recombinant (His)
TMPY-04996
Species: Rat
Expression System: HEK293
Coagulation Factor II Protein, Mouse, Recombinant (His)
TMPY-01791
Species: Mouse
Expression System: HEK293
Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc)
TMPH-00038
Species: Agkistrodon contortrix
Expression System: E. coli
CPB2 Protein, Human, Recombinant (His)
TMPJ-00649
Species: Human
Expression System: Human Cells
Serpin B6 Protein, Human, Recombinant (E. coli, His)
TMPJ-00243
Species: Human
Expression System: E. coli
Antithrombin III Protein, Human, Recombinant (His)
TMPY-00916
Species: Human
Expression System: HEK293
Antithrombin III Protein, Cynomolgus, Recombinant (His)
TMPY-02471
Species: Cynomolgus
Expression System: HEK293
Prothrombin Protein, Human, Recombinant (His)
TMPH-01974
Species: Human
Expression System: Yeast
Prothrombin Protein, Human, Recombinant (His & SUMO)
TMPH-01975
Species: Human
Expression System: E. coli
Coagulation factor X/F10 Protein, Human, Recombinant (His)
TMPY-01101
Species: Human
Expression System: Baculovirus-Insect Cells
Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)
TMPY-02185
Species: Human
Expression System: HEK293
Apolipoprotein H/APOH Protein, Human, Recombinant (His)
TMPY-01278
Species: Human
Expression System: HEK293
Serpin D1 Protein, Mouse, Recombinant (His)
TMPY-01254
Species: Mouse
Expression System: HEK293
Thrombomodulin Protein, Rat, Recombinant (His)
TMPY-03271
Species: Rat
Expression System: HEK293
Serpin D1 Protein, Human, Recombinant (His)
TMPY-00917
Species: Human
Expression System: HEK293
Thrombomodulin Protein, Human, Recombinant (His)
TMPY-05829
Species: Human
Expression System: HEK293
Carboxypeptidase B2 Protein, Human, Recombinant (His)
TMPY-01631
Species: Human
Expression System: HEK293
Carboxypeptidase B2 Protein, Mouse, Recombinant (His)
TMPY-02505
Species: Mouse
Expression System: HEK293
Carboxypeptidase B2 Protein, Rat, Recombinant (His)
TMPY-04490
Species: Rat
Expression System: HEK293
MppA Protein, E. coli, Recombinant (His & SUMO)
TMPH-00706
Species: E. coli
Expression System: E. coli
CD147 Protein, Human, Recombinant (aa 138-323, hFc)
TMPH-00998
Species: Human
Expression System: HEK293
Serpin A1a Protein, Mouse, Recombinant (His)
TMPJ-00452
Species: Mouse
Expression System: Human Cells
RAN Protein, Human, Recombinant (GST)
TMPH-01419
Species: Human
Expression System: E. coli
SAR1A Protein, Human, Recombinant (GST)
TMPH-01420
Species: Human
Expression System: E. coli
Serpin E2 Protein, Human, Recombinant (His)
TMPJ-00796
Species: Human
Expression System: Human Cells
VEGFC Protein, Human, Recombinant (His & Avi)
TMPK-01043
Species: Human
Expression System: HEK293
VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-01044
Species: Human
Expression System: HEK293
Serpin A5 Protein, Human, Recombinant (His)
TMPJ-00490
Species: Human
Expression System: Human Cells
BICD2 Protein, Mouse, Recombinant (GST)
TMPH-02846
Species: Mouse
Expression System: E. coli
BCL6 Protein, Human, Recombinant (His)
TMPH-00999
Species: Human
Expression System: E. coli
Serpin A1e Protein, Mouse, Recombinant (His)
TMPJ-01069
Species: Mouse
Expression System: Human Cells
GPVI Protein, Mouse, Recombinant (His)
TMPJ-00605
Species: Mouse
Expression System: Human Cells
Serpin B6 Protein, Human, Recombinant (His)
TMPY-02242
Species: Human
Expression System: Baculovirus-Insect Cells
PDIA6 Protein, Human, Recombinant (His)
TMPJ-01124
Species: Human
Expression System: Human Cells
Serpin B12 Protein, Human, Recombinant (His)
TMPJ-01282
Species: Human
Expression System: Human Cells
VAMP3 Protein, Human, Recombinant (His)
TMPY-03604
Species: Human
Expression System: E. coli
Serpin B12 Protein, Mouse, Recombinant (His)
TMPY-01718
Species: Mouse
Expression System: Baculovirus-Insect Cells
Serpin A1 Protein, Human, Recombinant (aa 25-418, His)
TMPJ-00505
Species: Human
Expression System: Human Cells
Coagulation factor X/F10 Protein, Mouse, Recombinant (His)
TMPJ-00707
Species: Mouse
Expression System: Human Cells
Coagulation Factor X Protein, Human, Recombinant (hFc)
TMPJ-00301
Species: Human
Expression System: Human Cells
TREML1 Protein, Human, Recombinant (hFc)
TMPJ-00193
Species: Human
Expression System: Human Cells
Serpin E2 Protein, Mouse, Recombinant (His)
TMPJ-01083
Species: Mouse
Expression System: Human Cells
Thrombomodulin Protein, Mouse, Recombinant (His)
TMPJ-00857
Species: Mouse
Expression System: Human Cells
KNG1 Protein, Human, Recombinant (His)
TMPJ-00734
Species: Human
Expression System: Human Cells
Neuroserpin Protein, Mouse, Recombinant (His)
TMPY-02628
Species: Mouse
Expression System: HEK293
HGFA Protein (pro form), Human, Recombinant (His)
TMPY-00821
Species: Human
Expression System: HEK293
Neuroserpin Protein, Human, Recombinant (His)
TMPY-01241
Species: Human
Expression System: HEK293
F13A Protein, Human, Recombinant (His)
TMPJ-00535
Species: Human
Expression System: Human Cells
TLT-1/TREML1 Protein, Human, Recombinant (His)
TMPY-01840
Species: Human
Expression System: HEK293
Cat No. Product Name
L7500 Coagulation and Anticoagulation Compound Library

154 compounds
A unique collection of 154 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS);
TargetMol