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NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $48 | In Stock | |
5 mg | $122 | In Stock | |
10 mg | $197 | In Stock | |
25 mg | $397 | In Stock | |
50 mg | $589 | In Stock | |
100 mg | $843 | In Stock | |
500 mg | $1,730 | In Stock |
Description | NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux. |
Targets&IC50 | TXA2:3.9 µM, COX-1:1.5 µM |
In vitro | NP-313 (0-80 μM) inhibits platelet aggregation in a dose-dependent manner, reducing thrombin- and A23187-induced aggregation by up to 80% and 60%, respectively.[1] At concentrations of 0-8 μM, NP-313 concentration-dependently inhibits P-selectin expression and collagen- or thrombin-induced thromboxane B2 (TXB2) production in human platelets, and inhibits COX-1 and TXA2 synthase with IC50 values of 1.5 and 3.9 μM, respectively.[1] |
In vivo | NP-313 (4-16 µg/g; i.v.) significantly prolongs time-to-occlusion (TTO), prolongs bleeding time, and inhibits platelet aggregation induced by collagen (10 µg/mL) in male ICR mice.[1] |
Alias | NSC-4264, NSC4264, NSC 4264, NP 313 |
Molecular Weight | 249.65 |
Formula | C12H8ClNO3 |
Cas No. | 5397-78-4 |
Smiles | O=C1C=2C(C(=O)C(Cl)=C1NC(C)=O)=CC=CC2 |
Relative Density. | 1.44g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (240.34 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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