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H-D-Phe-Pip-Arg-pNA dihydrochloride

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COA HPLC

H-D-Phe-Pip-Arg-pNA dihydrochloride

Catalog No. T40711Cas No. 62354-65-8

H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, H-D-Phe-Pip-Arg-pNA dihydrochloride is employed for the quantification of antithrombin-heparin cofactor (AT-III). The AT-III assay utilizing this substrate is characterized by its sensitivity, accuracy, and ease of implementation.

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Pack Size	Price	Availability
1 mg	$179	In Stock
5 mg	$365	In Stock
10 mg	$543	In Stock
25 mg	$877	In Stock
50 mg	$1,180	In Stock
100 mg	$1,620	In Stock
1 mL x 10 mM (in DMSO)	$689	In Stock

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Product Introduction

Bioactivity

Description

Alias

S-2238 dihydrochloride, H-D-Phe-Pip-Arg-pNA dihydrochloride

Chemical Properties

Molecular Weight	625.55
Formula	C27H38Cl2N8O5
Cas No.	62354-65-8

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 125 mg/mL (199.82 mM)

DMSO: 125 mg/mL (199.82 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.5986 mL	7.9930 mL	15.9859 mL	79.9297 mL
5 mM	0.3197 mL	1.5986 mL	3.1972 mL	15.9859 mL
10 mM	0.1599 mL	0.7993 mL	1.5986 mL	7.9930 mL
20 mM	0.0799 mL	0.3996 mL	0.7993 mL	3.9965 mL
50 mM	0.0320 mL	0.1599 mL	0.3197 mL	1.5986 mL
100 mM	0.0160 mL	0.0799 mL	0.1599 mL	0.7993 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

substrateS-2238InhibitorS 2238inhibitS2238 Dihydrochloridefibrinogenantithrombin-heparinAT-IIIS2238HDPhePipArgpNA dihydrochlorideH D Phe Pip Arg pNA dihydrochloridechromogenicH-D-Phe-Pip-Arg-pNA DihydrochloridecofactorthrombinH-D-Phe-Pip-Arg-pNAS 2238 DihydrochlorideS-2238 Dihydrochloride