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Dabigatran ethyl ester hydrochloride

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Purity:98.7%

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COA HNMR HPLC

Dabigatran ethyl ester hydrochloride

Catalog No. T10951Cas No. 211914-50-0

Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$89	In Stock
25 mg	$163	In Stock
50 mg	$288	In Stock
100 mg	$448	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock

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Product Introduction

Bioactivity

Description	Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.
In vitro	Dabigatran (ethyl ester hydrochloride) has a Ki of 0.9 μM for NQO2 and an IC50 of 0.8 μM. The ethyl group (ethyl ester hydrochloride) of dabigatran significantly extends the interaction surface, especially with hydrophobic amino acids (such as Ile 128 and Met 154). Dabigatran ethyl ester has a higher affinity for thrombin and NQO2 than dabigatran [1]. Dabigatran is a highly selective, reversible and effective thrombin inhibitor, which can be taken orally as a prodrug dabigatran etexilate .
In vivo	Dabigatran (Ki = 4.5 nM) can selectively bind to human thrombin and reversibly achieve a strong and lasting anticoagulant effect.

Chemical Properties

Molecular Weight	536.03
Formula	C27H30ClN7O3
Cas No.	211914-50-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (93.28 mM)

H2O: 5 mg/mL (9.33 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.8656 mL	9.3278 mL	18.6557 mL	93.2784 mL
5 mM	0.3731 mL	1.8656 mL	3.7311 mL	18.6557 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1866 mL	0.9328 mL	1.8656 mL	9.3278 mL
20 mM	0.0933 mL	0.4664 mL	0.9328 mL	4.6639 mL
50 mM	0.0373 mL	0.1866 mL	0.3731 mL	1.8656 mL
100 mM	0.0187 mL	0.0933 mL	0.1866 mL	0.9328 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc