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Thrombin (MW 37kDa)
Catalog No. T19580Cas No. 9002-04-4
Alias Thrombin
Thrombin (MW 37kDa) is an allosteric serine protease with trypsin-like activity.
Thrombin (MW 37kDa)
Catalog No. T19580Alias ThrombinCas No. 9002-04-4
Thrombin (MW 37kDa) is an allosteric serine protease with trypsin-like activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1000 U | $139 | In Stock | |
| 2000 U | $232 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Thrombin (MW 37kDa) is an allosteric serine protease with trypsin-like activity. |
| In vitro | Low concentrations of thrombin and thrombin preconditioning yield the potential of rescuing cells and to induce survival of neurons and astrocytes exposed to various ischemic insults[1]. |
| In vivo | Elevated thrombin activity was found in the brain slices from mice that were treated (in vitro and in vivo) with paraoxon. Increased levels of PAR-1 and pERK proteins and decreased prothrombin mRNA were found in the brains of paraoxon-treated mice. Furthermore, ex vivo and in vivo electrophysiological experiments showed that exposure to paraoxon causes elevated electrical activity in CA1 and CA3 regions of the hippocampus. Moreover, a specific PAR-1 antagonist (SCH79797) reduced this activity. Altogether, these results reveal the importance of thrombin and PAR-1 in paraoxon poisoning[2]. |
| Alias | Thrombin |
| Molecular Weight | 37kDa |
| Cas No. | 9002-04-4 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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