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Argatroban

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Purity:100%

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COA HPLC HNMR

Argatroban

Catalog No. T0155Cas No. 74863-84-6

Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.

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Pack Size	Price	Availability
5 mg	$33	In Stock
10 mg	$54	In Stock
25 mg	$105	In Stock
50 mg	$163	In Stock
100 mg	$247	In Stock
200 mg	$368	In Stock
500 mg	$596	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Product Introduction

Bioactivity

Description	Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
Targets&IC50	Thrombin:5-39 nM(Ki)
In vitro	In a rat distal cerebral artery occlusion model, administration of Argatroban at a dose of 0.3 mg/hour significantly reduced the number of microthrombi following artery occlusion. Argatroban treatment (at 0.1 and 0.3 mg/hour) notably reversed the decline in local cerebral blood flow in rats with distal cerebral artery occlusion.
In vivo	Argatroban directly induces phenotypic transformation in vascular smooth muscle cells, upregulating the expression of myofilament-related proteins, PAI-1, and β-actin mRNA. In animal models with thrombosis rich in platelets and erythrocytes, Argatroban (ED50=125 μg/kg) demonstrates antithrombotic effects. It exhibits antithrombin activity across a range (Ki=5 nM-39 nM).
Alias	MCI-9038, MD-805, Argipidine

Chemical Properties

Molecular Weight	508.63
Formula	C23H36N6O5S
Cas No.	74863-84-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 6 mg/mL (11.79 mM)

DMSO: 45 mg/mL (88.47 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9661 mL	9.8303 mL	19.6607 mL	98.3033 mL
5 mM	0.3932 mL	1.9661 mL	3.9321 mL	19.6607 mL
10 mM	0.1966 mL	0.9830 mL	1.9661 mL	9.8303 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0983 mL	0.4915 mL	0.9830 mL	4.9152 mL
50 mM	0.0393 mL	0.1966 mL	0.3932 mL	1.9661 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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