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Argatroban
🥰Excellent
Catalog No. T0155Cas No. 74863-84-6
Alias MD-805, MCI-9038, Argipidine
Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
Argatroban
🥰Excellent
Purity: 100%
Catalog No. T0155Alias MD-805, MCI-9038, ArgipidineCas No. 74863-84-6
Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $33 | In Stock | |
| 10 mg | $54 | In Stock | |
| 25 mg | $105 | In Stock | |
| 50 mg | $163 | In Stock | |
| 100 mg | $247 | In Stock | |
| 200 mg | $368 | In Stock | |
| 500 mg | $596 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi. |
| Targets&IC50 | Thrombin:5-39 nM(Ki) |
| In vitro | In a rat distal cerebral artery occlusion model, administration of Argatroban at a dose of 0.3 mg/hour significantly reduced the number of microthrombi following artery occlusion. Argatroban treatment (at 0.1 and 0.3 mg/hour) notably reversed the decline in local cerebral blood flow in rats with distal cerebral artery occlusion. |
| In vivo | Argatroban directly induces phenotypic transformation in vascular smooth muscle cells, upregulating the expression of myofilament-related proteins, PAI-1, and β-actin mRNA. In animal models with thrombosis rich in platelets and erythrocytes, Argatroban (ED50=125 μg/kg) demonstrates antithrombotic effects. It exhibits antithrombin activity across a range (Ki=5 nM-39 nM). |
| Alias | MD-805, MCI-9038, Argipidine |
| Molecular Weight | 508.63 |
| Formula | C23H36N6O5S |
| Cas No. | 74863-84-6 |
| Smiles | S(N[C@H](C(=O)N1[C@@H](C(O)=O)C[C@H](C)CC1)CCCNC(=N)N)(=O)(=O)C2=C3C(=CC=C2)CC(C)CN3 |
| Relative Density. | 1.47 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 6 mg/mL (11.79 mM) DMSO: 45 mg/mL (88.47 mM)  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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