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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $33 | In Stock | |
10 mg | $54 | In Stock | |
25 mg | $105 | In Stock | |
50 mg | $163 | In Stock | |
100 mg | $247 | In Stock | |
200 mg | $368 | In Stock | |
500 mg | $596 | In Stock | |
1 mL x 10 mM (in DMSO) | $48 | In Stock |
Description | Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi. |
Targets&IC50 | Thrombin:5-39 nM(Ki) |
In vitro | In a rat distal cerebral artery occlusion model, administration of Argatroban at a dose of 0.3 mg/hour significantly reduced the number of microthrombi following artery occlusion. Argatroban treatment (at 0.1 and 0.3 mg/hour) notably reversed the decline in local cerebral blood flow in rats with distal cerebral artery occlusion. |
In vivo | Argatroban directly induces phenotypic transformation in vascular smooth muscle cells, upregulating the expression of myofilament-related proteins, PAI-1, and β-actin mRNA. In animal models with thrombosis rich in platelets and erythrocytes, Argatroban (ED50=125 μg/kg) demonstrates antithrombotic effects. It exhibits antithrombin activity across a range (Ki=5 nM-39 nM). |
Alias | MCI-9038, MD-805, Argipidine |
Molecular Weight | 508.63 |
Formula | C23H36N6O5S |
Cas No. | 74863-84-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 6 mg/mL (11.79 mM) DMSO: 45 mg/mL (88.47 mM) ![]() H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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