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Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $43 | In Stock | |
10 mg | $61 | In Stock | |
25 mg | $88 | In Stock | |
50 mg | $116 | In Stock | |
100 mg | $162 | In Stock | |
500 mg | $397 | In Stock | |
1 mL x 10 mM (in DMSO) | $71 | In Stock |
Description | Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. |
Targets&IC50 | FXa:0.561 nM(Ki) |
In vitro | In thrombosis models involving rats and rabbits, Edoxaban demonstrates a dose-dependent inhibition of thrombus formation. Edoxaban (p.o.) elicits effective anti-Xa activity and achieves high plasma drug concentrations in both rats and monkeys. |
In vivo | Edoxaban (0.256 and 0.508 μM) doubles the prothrombin time in human plasma and partially activates the thromboplastin time. |
Alias | edoxaban tosylate hydrate, DU-176b tosylate Monohydrate, DU-176b monohydrate |
Molecular Weight | 738.27 |
Formula | C31H40ClN7O8S2 |
Cas No. | 1229194-11-9 |
Smiles | O.Cc1ccc(cc1)S(O)(=O)=O.CN(C)C(=O)[C@H]1CC[C@H](NC(=O)C(=O)Nc2ccc(Cl)cn2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 93 mg/mL (126 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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