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Edoxaban Tosylate Monohydrate

🥰Excellent
Catalog No. T2368Cas No. 1229194-11-9
Alias edoxaban tosylate hydrate, DU-176b tosylate Monohydrate, DU-176b monohydrate

Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.

Edoxaban Tosylate Monohydrate

Edoxaban Tosylate Monohydrate

🥰Excellent
Purity: 99.97%
Catalog No. T2368Alias edoxaban tosylate hydrate, DU-176b tosylate Monohydrate, DU-176b monohydrateCas No. 1229194-11-9
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Pack SizePriceAvailabilityQuantity
5 mg$43In Stock
10 mg$61In Stock
25 mg$88In Stock
50 mg$116In Stock
100 mg$162In Stock
500 mg$397In Stock
1 mL x 10 mM (in DMSO)$71In Stock
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Purity:99.97%
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Product Introduction

Bioactivity
Description
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Targets&IC50
FXa:0.561 nM(Ki)
In vitro
In thrombosis models involving rats and rabbits, Edoxaban demonstrates a dose-dependent inhibition of thrombus formation. Edoxaban (p.o.) elicits effective anti-Xa activity and achieves high plasma drug concentrations in both rats and monkeys.
In vivo
Edoxaban (0.256 and 0.508 μM) doubles the prothrombin time in human plasma and partially activates the thromboplastin time.
Aliasedoxaban tosylate hydrate, DU-176b tosylate Monohydrate, DU-176b monohydrate
Chemical Properties
Molecular Weight738.27
FormulaC31H40ClN7O8S2
Cas No.1229194-11-9
SmilesO.Cc1ccc(cc1)S(O)(=O)=O.CN(C)C(=O)[C@H]1CC[C@H](NC(=O)C(=O)Nc2ccc(Cl)cn2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (126 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3545 mL6.7726 mL13.5452 mL67.7259 mL
5 mM0.2709 mL1.3545 mL2.7090 mL13.5452 mL
10 mM0.1355 mL0.6773 mL1.3545 mL6.7726 mL
20 mM0.0677 mL0.3386 mL0.6773 mL3.3863 mL
50 mM0.0271 mL0.1355 mL0.2709 mL1.3545 mL
100 mM0.0135 mL0.0677 mL0.1355 mL0.6773 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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